Variability Of Glucose And Lifestyle In Continuous Glucose Monitoring (CGM)

Hiroshi BANDO1,2, Yoshikane KATO3, Setsuko KANAZAWA3, Mayumi TANAKA3, Etsuko SUEKI3, Hiroe KANAGAWA3, Takafumi KAWATA3, Atsuko KAWAHITO3

1Tokushima University / Medical Research, Tokushima, Japan

2Japan Low Carbohydrate Diet Promotion Association, Kyoto, Japan

3Kanaiso Hospital, Tokushima, Japan

Corresponding Author: Hiroshi BANDO, MD, PhD, FACP
Address: Tokushima University / Medical Research, Nakashowa 1-61, Tokushima 770-0943, Japan.

Received date: 17 July 2018; Accepted date: 29 July 2018; Published date: 2 August 2018


Background: Investigation of glucose variability is crucial for a patient with Type 1 Diabetes mellitus (T1DM) on insulin treatment. For Continuous Glucose Monitoring (CGM), FreeStyle Libre (Abbott) has been introduced to clinical practice with useful and beneficial efficacy.

Case and Results: The patient was 55 year-old T1DM female with body mass index (BMI) 21 kg/m2, HbA1c 8.0 %. She was on CGM for 14 days, with obtained glucose data in every 15 minutes. Treatment included multiple daily insulin injections (MDI) of Insulin Aspart 3 times and Insulin Glargin once a day. She showed unstable blood glucose variability with hyperglycemia and hypoglycemia, besides 2 hours delay shift in daily lifestyle rhythm. There was a discrepancy of HbA1c between actual value 8.0% and the presumed value 6.9% by FreeStyle Libre.

Discussion and Conclusion: Obtained glucose data from FreeStyle Libre have been satisfactory. One reason for lower HbA1c value would be from the characteristic tendency in lower glucose region. Larger distribution of glucose variability would be due to delayed shift of lifestyle, sleep situation and irregular meal. These results would become the basal data for CGM, the reference to better modification of MDI and clinical diabetic practice in future research.

Citation: Bando H, Kato Y, Kanazawa S et al., “Variability Of Glucose And Lifestyle In Continuous Glucose Monitoring (CGM)”, Asp Biomed Clin Case Rep, vol.1, no.1: 1-6, 2018.

Copyright © 2018 Bando H, Kato Y, Kanazawa S et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Key Words: Continuous Glucose Monitoring (CGM); FreeStyle Libre; Type 1 Diabetes Mellitus (T1DM); Mean Absolute Relative Difference (MARD); Low Carbohydrate Diet (LCD)

Abbreviation: Continuous Glucose Monitoring (CGM); Type 1 Diabetes Mellitus (T1DM); Mean Absolute Relative Difference (MARD); Diabetes Control and Complications Trial (DCCT); Epidemiology of Diabetes Interventions and Complications (EDIC); Low Carbohydrate Diet (LCD); Morbus (M) value; Clinical and Laboratory Standards Institute (CLSI); Subcutaneous Continuous Glucose Monitoring System (SC-CGM); Multiple Daily Insulin (MDI) Injection



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