Asploro Journal of Biomedical and Clinical Case Reports
Asploro Journal of Biomedical and Clinical Case Reports
Asploro Journal of Biomedical and Clinical Case Reports [ISSN: 2582-0370]
ISSN: 2582-0370 | Volume-5

About Asploro Journal of Biomedical and Clinical Case Reports [ASJBCCR]

Asploro Journal of Biomedical and Clinical Case Reports is an open access, peer-reviewed journal which mainly aims to directly improve global health outcomes and share clinical knowledge using case reports to convey important best practice messages. Each case report published in this journal adds valuable new information to medical knowledge.

Case Reports are the first piece of research writing in the health field and represent the most basic type of study design. They make a contribution to health knowledge and have educational value or highlight the need for a change in clinical practice or diagnostic/prognostic approaches. If your submission has an important clinical message we would like to read it!

ASJBCCR welcomes original case reports that expands the field of general medical knowledge, clinical images, procedural videos, original research relating to case reports, and short communications from all areas of Medicine, Nursing, Dentistry, and Veterinary Science. Case reports can span the full spectrum of health sciences in the broadest sense, including biochemistry, microbiology, developmental biology, cell biology, genetics, immunology, molecular biology, structural biology, translational medicine, protein science, clinical epigenetics, clinical trials, clinical pharmacology, physiology, neuroscience, etc.,

Submit manuscript as an e-mail attachment to the Editorial Office at editor.biomed@asploro.com

Why Publish With Us

  • All the published articles are open access which means it’s free to access from anywhere in the world.
  • We offer fast publication while providing rigorous peer review to maintain the integrity of information.
  • Each article will be published under a Creative Commons license and authors are the copyright holder.
  • We are committed to the highest standards of peer review.
  • We’re proud of the impact and influence this journal have – from citations to social media shares.
  • We’re committed to promoting your work as widely as we can and providing as much visibility and exposure for your article as possible.

Most Recent Articles


Anaplastic Multiple Myeloma: Case Series and Literature Review
Case Series | Asp Biomed Clin Case Rep. 2022 Jan 15;5(1):1-11 | DOI: 10.36502/2022/ASJBCCR.6255
Anaplastic Multiple Myeloma: Case Series and Literature Review

Author(s): Jian Wu, Emily Chu, Cristiana Costa Chase, Taewoong Choi, Cristina Gasparetto, Ken Young, Yubin Kang*

Abstract

Background: Anaplastic multiple myeloma (AMM) is a very rare but distinct subtype of multiple myeloma (MM) with an extremely poor prognosis. Due to its rarity, AMM lacks detailed descriptions and clear definitions. Moreover, there is no consensus on the treatment and evidence suggests that AMM responds poorly to several novel therapies. We conducted a literature review and retrospective case series to determine clinical characteristics, pathological features, and outcomes of AMM.
Case Presentation: Published case reports and case series of AMM since 1983 were systematically extracted and reviewed. A total of 52 patients with AMM were reported in the PUBMED since 1983, including 26 males (50%) and 26 females (50%). The age ranged from 29 years old to 85 years old, with a mean age of 57.02 years old. Most of the patients presented with bone pain (23, 44.2%), fatigue (18, 34.6%), plasmacytoma (18, 34.6%) and weight loss (7, 13.5%). The median survival of the patients was 4 months. To investigate the outcomes of patients with AMM in the current era of treatment, a series of 14 patients with AMM diagnosed at our institute between December 2012 and July 2021was retrospectively analyzed. Our retrospective case series consisted of 12 males (85.7%) and 2 females (14.3%), with a mean age of 59 years old. Most of our AMM patients displayed bone lytic lesions as a common manifestation. The common cytogenetic abnormality was 1q amplification. All patients received standard combination chemotherapy consisting of proteasome inhibitors and/or immunomodulatory agents, and half of the patients underwent autologous hematopoietic stem cell transplantation. The median progression-free survival (PFS) and overall survival (OS) for our 14 AMM patients were 0.84 years and 1.52 years, respectively, which was significantly worse than the regular MM patients treated at our institute from 2003-2013 who had a PFS of 2.28 years and OS of 4.92 years.
Conclusions: AMM is a very rare, morphologically distinct variant of MM. It has adverse cytogenetics and an aggressive course. It is often resistant to standard chemotherapy and presents with an extremely low survival rate.

Asploro Journal of Biomedical and Clinical Case Reports [ISSN: 2582-0370]
Commentary | Asp Biomed Clin Case Rep. 2021 Nov 16;4(3):191-94 | DOI: 10.36502/2021/ASJBCCR.6253
Several Effective Measures for Minus Excess Mortality of COVID-19 in Japan Including Mutual Interrelationships and Long-Term Care Facilities (LTCF)

Author(s): Hiroshi Bando*

Abstract

The impact of COVID-19 can be shown by life expectancy, excess death and total years of life lost (YLL). United States showed life expectancy minus 1.67 years, excess deaths 375,235 and total YLL 7,362,555. The excess death of Japan has remained minus value for long, in which long-term care facilities (LTCF) may contribute. LTCF has characteristic points as i) mutual interrelationships between hospitals, medical societies and prefectural offices, ii) rapid communication channels for regulatory official authorities, iii) high degree of citizenship and cooperation of all Japanese people for daily life and iv) mild lockdown without any punishment with declaration.

Asploro Journal of Biomedical and Clinical Case Reports [ASJBCCR] [ISSN: 2582-0370]
Case Series | Asp Biomed Clin Case Rep. 2021 Oct 26;4(3):170-78 | DOI: 10.36502/2021/ASJBCCR.6250
Congenital Constriction Band Syndrome: Clinical Study of Three Cases in Togo

Author(s): Foli Agbeko*, Fidèle Comlan Dossou, Mawouto Fiawoo, Elom Ounoo Takassi, Mawuse Koffi Guédénon, Kokou Agbékogni Réné Segbedji, Djatougbé Ayaovi Elie Akolly, Magnoulelem N’Zonou, Sollim Talboussouma, Mazama Pakoudjare, Homba Daké Batalia, Kokouvi Evenyo Abalo, Edem Koffi Djadou, Kokou Nadiedjoa Douti, Adama Dodji Gbadoe, Yawo Dzayissé Atakouma, Didier Koffi Gnamey

Abstract

Introduction: Congenital constriction band syndrome (CCBS) or amniotic band syndrome is a complex set of congenital malformations, mainly affecting the limbs, but also the craniofacial and thoraco-abdominal region.
The Patients: The purpose of this work is to describe the clinical and diagnostic aspects of CCBS in Togo in relation to 03 clinical cases.
The Primary Diagnoses, Interventions, and Outcomes: The first case is characterized by an asymmetric bilateral superficial constriction groove of the lower limbs, pseudosyndactylias and synostosis of the tibia and fibula on X-ray. The second has a deep strangulation in the left arm with an amputation of the fingers associated with hypochromic skin lesions, poorly hemmed polylobal ear and skin growths. The latter characterized by persistent bridle, strangulation and ischemia downstream of that of the left wrist with postnatal amputation of the left hand.
Conclusion: The strengthening of antenatal diagnosis, the introduction of genetic counselling and the establishment of a national malformations register should make it possible to improve the management of cases of amniotic flange disease.

A Case Report of Delayed Hemothorax Complicated by Fibrothorax
Case Report | Asp Biomed Clin Case Rep. 2021 Nov 02;4(3):184-90 | DOI: 10.36502/2021/ASJBCCR.6252
A Case Report of Delayed Hemothorax Complicated by Fibrothorax

Author(s): Tanvi Chokshi, Alexandra Theodosopoulos, Ethan Wilson, Michael Ysit, Sameir Alhadi, Leonard Ranasinghe*

Abstract

Delayed hemothorax is a potentially life-threatening complication of thoracic trauma that should be carefully considered in all patients presenting with thoracic injury. We report a case of delayed hemothorax in a 77-year-old male presenting eleven days’ status post multiple right mid- to high-rib fractures. His case was complicated by retained hemothorax after CT-guided chest-tube with subsequent video-assisted tube thoracostomy (VATS) revealing fibrothorax necessitating conversion to open thoracotomy. Known risk factors for development of delayed hemothorax include older patient age, three or more rib fractures, and presence of mid- to high-rib fractures, and should be used in risk stratification of thoracic trauma. Tube thoracostomy is often sufficient in management of delayed hemothorax. In rare cases, hemothoraces can be complicated by retained hemothorax or fibrothorax, which require more invasive therapy and carry greater morbidity and mortality.

Asploro Journal of Biomedical and Clinical Case Reports [ASJBCCR] [2582-0370]
Case Report | Asp Biomed Clin Case Rep. 2021 Oct 27;4(3):179-83 | DOI: 10.36502/2021/ASJBCCR.6251
Case Report and Highlight Clues on the Diagnosis of Pilomatrical Carcinoma

Author(s): Lewkowicz María de los Milagros*, Greco Daniel Alejandro, Lezcano Félix Gabriel, Cachau Victoria, Díaz de la Fuente Florencia

Abstract

Pilomatrical Carcinoma (PC) is a rare malignant adnexal tumor with matrical differentiation. Its benign counterpart (Pilomatrixoma) is diagnosed much more frequently in daily pathological practice. Both entities share genetic alterations but the malignant counterpart acquires mutations that make it develop an aggressive behavior.

We describe a 33-year-old man who presented with a 7 x 6 cm nodular ulcerated lesion in the left ear with markedly accelerated growth in the last month. Incisional biopsy was referred to us with suspicion of squamous cell carcinoma versus pyogenic granuloma.

Histologic sections showed ulcerated fragments infiltrated by a basaloid cell proliferation interspersed with groups of “ghost cells”. The neoplastic cells were arranged in irregular sheets with infiltrative borders. Groups of Squamous cells with trichilemmal keratinization and foci of necrosis were also identified. The biopsy was diagnosed as an adnexal neoplasm with pilomatrical differentiation, suggesting its complete resection with safety margins due to the presence of aggressive characteristics. The subsequent study of the excisional biopsy showed similar characteristics to those previously described. Notoriously, focal infiltration of the auricular cartilage was identified, leading us to the undoubted diagnosis of pilomatrical carcinoma.

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