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Asploro Journal of Biomedical and Clinical Case Reports

ISSN: 2582-0370

Asploro Journal of Biomedical and Clinical Case Reports

About this Journal

Asploro Journal of Biomedical and Clinical Case Reports is an open access, peer-reviewed journal which mainly aims to directly improve global health outcomes and share clinical knowledge using case reports to convey important best practice messages. Each case report published in this journal adds valuable new information to medical knowledge.

Case Reports are the first piece of research writing in the health field and represent the most basic type of study design. They make a contribution to health knowledge and have educational value or highlight the need for a change in clinical practice…..

Submit manuscript as an e-mail attachment to the Editorial Office at editor.biomed@asploro.com or through online at Submit Manuscript

Associations and Collaborations

Asploro Journal of Biomedical and Clinical Case Reports is associated with Japanese Low Carbohydrate Diet Promotion Association – In Japan, Dr. Koji EBE, MD, PhD and colleagues have established Japanese LCD Promotion Association (JLCDPA) and developed their activities as follows:

i) Beneficial information of LCD on the website concerning 77 affiliated hospitals and clinics so far.

ii) Biannual journal about LCD, and frequent mail magazine dissemination.

iii) Seminars and workshops have continued for years, including 11 seminars and 19 cooking workshops in large cities.

Why Publish With Us

  • All the published articles are open access which means it’s free to access from anywhere in the world.
  • Each case published in this journal can improve health outcomes.
  • We offer fast publication while providing rigorous peer review to maintain the integrity of information.
  • Each article will be published under a Creative Commons license and authors are the copyright holder.
  • We are committed to the highest standards of peer review.
  • We’re proud of the impact and influence this journal have – from citations to social media shares.
  • We’re committed to promoting your work as widely as we can and providing as much visibility and exposure for your article as possible.

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Latest Papers

Abstract

Biosimilar medicines are highly similar to FDA approved reference biologics. The sponsor’s intended use claim plays an important role in the use of biosimilar medicines in specialty therapy categories such as immunology, endocrinology, oncology. The new biosimilar products approved by the FDA, play a pivotal role in the clinical treatments of patients suffering from life-threatening diseases such as cardiac myopathies, carcinoma, sarcoma, lymphoma. The US biosimilar approval process requires a thorough characterization of the new biosimilars with a clinically meaningful outcome. Sponsors of new biosimilars follow the appropriate ICH guidelines in regard to clinical PK/PD, safety and efficacy studies. The FDA guidances for extrapolation and interchangeability state that data derived from clinical studies should be adequate to demonstrate purity, potency, safety and the intended clinical use of the new biosimilar in comparison to previously approved licensed biologics. This article emphasizes the FDA’s quality system approach to the design of studies for clinical applications for designated specialty therapy categories.

Author(s): Smiti Y*, Oussama C, Othman A, Kallouch L, Omor Y, Latib R, El Ahmadi B, Ghannam A, Belkhadir Z
Abstract

Introduction: Pneumopericardium is defined as a collection of air or gas in the pericardium, and considered a rare and innocuous condition. It may progress to tension and cardiac tamponade and may become life-threatening in many instances. In this publication, we will share the case of a pneumopericardium which occurred for middle-aged women treated for liver carcinoma after a laparotomic surgery.

Discussion: Pneumopericardium was once defined as a collection of air or gas in the pericardium, and considered a rare and innocuous condition. The most common etiology of pneumopericardium is blunt trauma. Also, air may dissect into the mediastinum from the retroperitoneal space following the perforation of a hollow viscous or infection with gas-producing organisms. Other causes of pneumopericardium include iatrogenic complications during chest or abdominal surgeries. Diagnosis of spontaneous pneumopericardium can often be made with a formal two-view Chest X-Ray or CT scan. The treatment of air in the pericardial space depends on the type of pneumopericardium present and whether or not there is associated cardiac tamponade. However, tension pneumopericardium can be effectively relieved by pericardiocentesis or tube decompression and the underlying cause subsequently determined.

Conclusion: In conclusion, surgeons should be aware of the possibility of pneumopericardium for patients with chest pain after a laparoscopic procedure and look for electrocardiographic abnormalities. It is important to outline the important role of the chest CT scan to search for pneumothorax or pneumomediastinum.

Respiratory Distress after a Liver Surgery, Think at Pneumopericardium
Abstract

Introduction: Operative treatment of mallet finger fractures is generally recommended for patients in whom more than one-third of the articular surface is involved with volar subluxation. We present a case of conservative treatment with chronic nonunion of a mallet finger fracture after failed mallet finger surgery.

Presentation of Case: A 16-year-old boy presented with a bony fragment (mallet formation) of his left long finger. The fragment occupied 40% of the articular surface, with volar subluxation of the distal phalanx. Percutaneous needle curettage of the fracture site and pinning were performed. Six weeks later, the fragment was displaced and had rotated. Hence, all the pins were removed, and a splint was applied. The fracture displayed nonunion and volar subluxation of the distal phalanx. The patient continued with the splinting, and the fracture finally healed. At 27 months after the surgery, radiological examination showed very good remodeling of the distal interphalangeal joint surface with anatomic joint congruence. Functional results at 27 months were good according to Crawford’s classification.

Conclusion: Chronic nonunion of a mallet finger can be cured conservatively even when a fracture gap is seen along with displacement of the fragment and volar subluxation of the distal phalanx.

Conservative Treatment of Chronic Mallet Fracture Non-union after Failed Pin Fixation
Conservative Treatment of Chronic Mallet Fracture Non-union after Failed Pin Fixation

A 56-year old man, originally from Pakistan, presented with bilateral avascular necrosis of the hips on a background of emphysema, pulmonary fibrosis, coronary artery disease, diabetes type 2 and psoriasis. The cause of the avascular necrosis was unclear, with no recent trauma or steroid use. During his preoperative consultation, he presented dysautonomia requiring an inpatient investigation; the surgery was canceled. He reported a thirty-pound weight loss and a three-week history of night sweats and shortness of breath. While hospitalized, this gentleman presented subacute confusion and fluctuation of his sensorium, compatible with limbic encephalitis. Furthermore, he developed diffuse myokymia involving the axial and appendicular musculature, confirmed by EMG.

Author(s): Benkirane S*, BayBay H, Bennani M, Oulehri A, Mernissi FZ

Hidradenoma is a rare benign adnexal sweat gland tumor with eccrine or apocrine differentiation. In the skin, it is usually in the form of a solitary skin nodule. The treatment is complete surgical resection with healthy margins, given the high rate of recurrence and the possibility of malignant transformation. We report a case.

Nodular Hidradenoma Case of Rare Localization
Nodular Hidradenoma Case of Rare Localization

A 60-year-old man presented with left flank pain, a palpable abdominal mass, and hematuria for months. Computed tomography revealed a large tumor in the left kidney (approximately 17.7 cm in diameter) with evidence of left adrenal, left renal vein, and inferior vena cava (IVC) invasion. He underwent left nephrectomy with IVC thrombectomy. Transesophageal echocardiography (TEE) was used during the whole procedure and the tumor was found in the IVC (Fig-1) before resection.

After resection of the main tumor, pulseless electrical activity (PEA) following the sudden onset of hypotension was noticed during the snaring of the IVC. Cardiopulmonary resuscitation was performed and emergent cardiopulmonary bypass (CPB) was established. Newly discovered thrombi appeared in the right atrium (Fig-2), right ventricle, main pulmonary artery, and descending aorta; consequently, these were resected to remove the thrombi.

Weaning from CPB was difficult, with poor left ventricle wall motion noted on TEE. Since the left coronary artery was not seen, coronary obstruction by tumor thrombi was suspected. Therefore, coronary artery bypass graft operation was performed from the ascending aorta to the left anterior descending artery using a harvested autologous saphenous vein.

Intraoperative Cardiogenic Shock Caused by Intracardiac Tumor Thrombi Obstruction
Intraoperative Cardiogenic Shock Caused by Intracardiac Tumor Thrombi Obstruction
Abstract

Poor complementary feeding contributes to the characteristic negative growth trends leading to death as well. Therefore, the present study aimed to assess complementary feeding practices and associated factors in the selected urban area of Nepal.

A community-based cross-sectional study was conducted among 237 mothers having children aged 6-23 months in Bhaktapur Municipality. Pretested structured questionnaire was used to collect data using a face-to-face interview. Data were entered in Excel followed by using Statistical Package for Social Sciences (SPSS) version 20. Multinomial logistic regression was conducted to determine the feeding practices of infants as per WHO recommendation.

Out of the 237 children, 54.8% were boys and 42.2% were girls. In this study 61% were breastfed within 1 hour of birth, 33% were given pre-lacteal feeding, 19% were given complementary feed on time, 55.3% had good minimum meal frequency, and 47.70% were given minimum number of food groups and 26.5% were practicing good minimum acceptable diet. Total Kcal intake supplied is equal to WHO recommended standard however, triggering 84% of participants included processed food as a part of complementary feeding which is never the good practice.

The majority of mothers lack the knowledge regarding ideal feeding practices as calorie intake was equal to WHO recommendation. There was a gap in knowledge and practice regarding duration of exclusive breastfeeding and initiation and continuation of ideal complementary feeding. The rate of complementary feeding was found on declining trend. Emphasis given to educate mothers about complementary feeding practices can be very useful for the purpose.

Complementary Feeding Practices and it's Associated Factors Among Mothers in Selected Urban Area of Nepal
Complementary Feeding Practices and it's Associated Factors Among Mothers in Selected Urban Area of Nepal
Abstract

The 26-year-old woman was diagnosed with type 1 diabetes in 2014. The diagnosis was confirmed while there was a slight increase in blood glucose and HbA1c levels using oral glucose tolerance test, determination of insulin levels and GADA testing. This was followed by a 2-year period with complete remissions and partial remissions of 2-8 U daily basal insulin glargine. Thereafter, the patient became pregnant. The minimal basal insulin used to date has been switched to human rapid-acting and NPH insulins five times daily, which had to be increased to 11 times the initial dose in the third trimester of pregnancy. After a successful spontaneous birth of a healthy baby girl, our patient wished to return to one-tenth of the maximum insulin dose that was used during pregnancy, to once daily insulin glargine. After three months, her blood glucose levels began to rise, with oral glucose challenge test showing a marked increase in blood glucose and a drastic reduction in C-peptide levels. This was when we switched to multiple daily insulin administration using glargine basal- and glulisine analogue insulins. Later, glargine was switched to insulin degludec, and with a 30-33 U total daily insulin dose and CGM for the past two years, the patient was in a satisfactory metabolic state.

Healthy Pregnancy and Birth during Unusually Long-Lasting Remission of Type-1 Diabetes: Case Report
Healthy Pregnancy and Birth during Unusually Long-Lasting Remission of Type-1 Diabetes: Case Report