Asploro Journal of Biomedical and Clinical Case Reports is an open access, peer-reviewed journal which mainly aims to directly improve global health outcomes and share clinical knowledge using case reports to convey important best practice messages. Each case report published in this journal adds valuable new information to medical knowledge.
Journal of Health Care and Research is an open access international journal publishing original peer-reviewed research articles. The Journal is a Tri-annually Publication. It is dedicated to the production of commitments in all fields of exploratory and connected inquires about health sciences. The editors welcome unique commitments that have not been published and are not under thought somewhere else.
Diabetes Research: Open Access is an Open Access Journal which releases Scholarly Articles featuring the content about Diabetes and Endocrinology.
The extent of the journal incorporates endocrine organs, hormonal discharges, hormonal receptors and the hormone controlled metabolic pathways. It also includes the clinical investigation of disorders related to Diabetes.
Asploro Journal of Pediatrics and Child Health is an international peer-reviewed open access journal in which it addresses not only health related issues but also aims to cover topics related to the physical, emotional and social well-being of children. Child psychology, behavioral aspects, societal apathy, exposure to the criminal and violent environment, parental negligence, and cultural background, are some of the factors that influence the development of a child; and any research related to these issues will be accepted for publication.
Most Recent Articles
Case Report | Asp Biomed Clin Case Rep. 2021 Apr 06;4(1):77-83 | DOI: 10.36502/2021/ASJBCCR.6233
Author(s): Hiroshi Bando*, Yoshinobu Kato, Yoshikane Kato, Sayuri Matsuzaki, Shinnichi Waka, Katsunori Ogura
The patient is a 56-year old (yo) female with type 2 diabetes mellitus (T2DM). Medical histories include persisting T2DM from 35yo, renal stone at 43yo, hypertension from 45yo, photocoagulation for retinopathy on 54yo. An incidentaloma was found in the left adrenal gland, where endocrinological exams were negative for functional tumor. Her diabetic control situation became worse with HbA1c > 10%, then the treatment has been changed from multiple daily injection (MDI), Dulaglutide to Xultophy which is combined agents of degludec and liraglutide (IDegLira). It was provided 10-18 doses daily, and then glucose variability profile was improved satisfactory, suggesting the dual synergistic effects.
Original Article | Asp J Pediatrics Child Health. 2021 Mar 02;3(1):18-29 | DOI: 10.36502/2021/asjpch.6164
Author(s): Marie Brunelli*, Li Niu, Christine Soghomonian, Anthony Salandy
his study aims to understand the association among sport participation, substance use and mental health of adolescent athletes within a diverse urban youth population. Data included a convenience sample of predominantly Black and Hispanic youth (85.7%) ages 14 to 18 years, who were Mount Sinai Adolescent Health Center (MSAHC) patients who presented for an annual physical exam or pre-participation exam (PPE) and were cleared for high school sport(s) participation. During the encounter, participants self-reported their use of tobacco, alcohol, and marijuana on a 6-point frequency scale, dichotomized to indicate use in the past 30 days. Anxiety and depression were assessed using two self-reported questions. Demographic data (e.g. ethnicity, gender, age) and whether participants had a current mental health provider were also extracted from the Electronic Medical Record (EMR). Results from multivariate logistic regression analyses showed adolescents with one year of sport participation had significantly lower odds of alcohol use in the past 30 days (OR=0.22, 95%CI= [0.12,0.41]) compared to individuals who did not participate in sport(s). Adolescents with two or more years of sport participation had significantly lower odds of alcohol (OR=0.46, 95%CI= [0.23,0.93]) and marijuana use (OR=0.10, 95%CI= [0.01,0.72]) in the past 30 days compared to individuals who did not participate in sport(s). Adolescents with one year of sport participation had lower odds of reported depression (OR=0.56, 95%CI= [0.33,0.94]) compared to individuals who did not participate in sport(s). Adolescents with two or more years of sport participation had significantly lower odds of reported depression (OR=0.35, 95%CI= [0.16,0.75]) and anxiety (OR=0.36, 95%CI= [0.15,0.86]) compared to individuals with no sport participation. These effects were found after adjusting for whether they were currently engaged with a mental health provider. Results of this study suggest that engagement in organized sport(s) may have protective effects against substance use, depression and anxiety. Additionally, the PPE could be used as an opportunity to promote engagement in extracurricular activities in addition to organized sports, to maximize the opportunity for adolescents to experience these benefits.
Review Article | Asp J Pediatrics Child Health. 2021 Mar 01;3(1):11-17 | DOI: 10.36502/2021/asjpch.6163
Author(s): Sarah Rotondo-Trivette, Sonia Michail*
Inflammatory bowel disease is an important pediatric disease, with as many as 25% of cases presenting during childhood. In this article, we review the types, etiology epidemiology, presentation, diagnosis, and management of pediatric inflammatory bowel disease. We also highlight the unique aspects of pediatric-onset inflammatory bowel disease versus adult-onset and future directions in this field, such as the use of genetic studies and ultrasound for the management of pediatric patients with inflammatory bowel disease.
Case Report | Asp Biomed Clin Case Rep. 2021 Mar 12;4(1):72-76 | DOI: 10.36502/2021/ASJBCCR.6232
Author(s): Foli Yvon Agbeko*, Mawouto Fiawoo, Rollin Arnaud Djomaleu, Magnoulelem NZonou, Sollim Talboussouma, Manani Hemou, Homba Daké Batalia, Rachel Bayahou Kérékou, Mazama Pakoudjare, Kokouvi Evenyo Abalo, Bayaki Saka, Deladem Koffi Azoumah, Edem Koffi Djadou, Kokou Nadiedjoa Douti, Komlatsè Gamedzi Akakpo-Numado, Adama Dodji Gbadoe, Yawo Dzayissé Atakouma
Introduction: CHD is a condition, which is frequent in pediatrics in the Caucasian population, remains rare in the Black population, and exceptional in sub-Saharan Africa.
The Patient: We report this first Togolese case of bilateral congenital dislocation of the hip associated with genu recurvatum observed in a newborn received on the second day of life.
The Primary Diagnoses, Interventions, and Outcomes: The pediatric examination had noted extension of lower limbs. The thighs were in adduction with a stiff bilateral genu recurvatum. The abduction of the thighs on the pelvis was considerably limited. The Barlow and Ortolani maneuvers showed a protrusion. There was also a camptodactyly of the thumbs and a cleft palate. The rest of the examination was normal. Ultrasound of the hip showed a bilateral congenital dislocation of the hip with an estimated acetabular fundus of 7 mm on both the right and left sides. Ultrasound and radiography of the knees were normal.
Conclusion: Clinical examination at birth is the key step in diagnosis of congenital hip dislocation. In situations where diagnosis is difficult, ultrasound is of capital importance. Treatment is in the majority of cases orthopedic.
Case Report | Asp Biomed Clin Case Rep. 2021 Mar 10;4(1):66-71 | DOI: 10.36502/2021/ASJBCCR.6231
Author(s): Domenico Russo, Massimo Mammucari*, Silvia Natoli, Enrica Maggiori, Luciano Antonaci, Renato Fanelli, Chiara Giorgio, Anna Rosa Catizzone, Fiammetta Troili, Alessandra Gallo, Costanza Guglielmo, Flora Canzona, Dario Dorato, Raffaele Di Marzo, Stefania Santini, Rodolfo Gallo, Piergiovanni Rocchi, Gianpaolo Ronconi, Paola E Ferrara, Michela Guarda
Drugs injected intradermally spread slowly into the underlying tissues and produce a drug-saving effect. The Italian society of mesotherapy suggested that intradermal therapy obtains analgesic effect on localized pain, with a lower risk of systemic drug interactions. We report a case of post-herpetic pain successfully treated by this technique. This case confirms that the intradermal administration technique (mesotherapy), which is based on the pathophysiology of the disorder, according to the recommendations, can contribute to the management of patients who do not tolerate standard therapies.
Case Report | Asp J Pediatrics Child Health. 2021 Feb 20;3(1):1-10 | DOI: 10.36502/2021/asjpch.6162
WES Reveals Novel Heterozygous NBAS Gene Mutations Associated with Fanconi Syndrome in a Patient with SOPH Syndrome: Case Report
Author(s): Jia Yean Thong, Zifeng Li, Alice Halim, Xiaochuan Wang, Michael Halim*, Xiaowen Zhai*
Variations in the NBAS gene is known to cause a spectrum of phenotypes ranging from isolated recurrent acute liver failure (RALF) to a multisystemic presentation known as SOPH syndrome. Patients with SOPH present with optic atrophy, acute liver failure, short stature, and Pelger-Huet anomaly. We report the presence of a novel pair of biallelic heterozygous mutations c.5139-5T>G and c.2203-2A>G in the NBAS gene of a patient with SOPH syndrome. A 9-year-old patient was clinically diagnosed with SOPH following clinical laboratory analyses. Current interventions for managing the disease encompass IVIG, methylprednisolone, calcium, and vitamin D administration. Whole-exome sequencing (WES) results showed two mutations: c.2203-2A>G and c.5139-5T>G, in the NBAS gene, which had not been previously reported. Notably, we hypothesize that NBAS mutations could potentially contribute to the development of Fanconi syndrome, a clinical diagnosis reported in our patient. Our study also supports the renaming of SOPH to SOPHIA to allow early detection and effective treatment.
Case Report | Asp Biomed Clin Case Rep. 2021 Feb 24;4(1):60-65 | DOI: 10.36502/2021/ASJBCCR.6230
Author(s): Luigi Urciuoli*, Elvira Guerriero
Coronavirus disease 2019 (COVID-19) is caused by a novel strain of coronavirus called severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which was first discovered in Wuhan, China, in December 2019. The virus has quickly spread around the globe and has been declared a global pandemic by the World Health Organization.
Although in COVID-19 respiratory symptoms predominate, there is a relevant body of evidence that initial symptoms and complications of COVID-19 are not limited to the pulmonary system, but can involve also the gastrointestinal tract.
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