Diabetes Research: Open Access

DROA

Diabetes Research: Open Access

About this Journal

Diabetes Research: Open Access is an Open Access Journal which releases Scholarly Articles featuring the content about Diabetes and Endocrinology.

The extent of the journal incorporates endocrine organs, hormonal discharges, hormonal receptors and the hormone controlled metabolic pathways. It also includes the clinical investigation of disorders related to Diabetes.

The articles including diabetes featured symptoms, causes, pathophysiology, conclusion,…

Submit manuscript as an e-mail attachment to the Editorial Office at diabresearch@clinicalsci.com or through online at Submit Manuscript

Associations and Collaborations

Diabetes Research: Open Access is associated with Japanese Low Carbohydrate Diet Promotion Association – In Japan, Dr. Koji EBE, MD, PhD and colleagues have established Japanese LCD Promotion Association (JLCDPA) and developed their activities as follows:

i) Beneficial information of LCD on the website concerning 77 affiliated hospitals and clinics so far.

ii) Seminars and workshops have continued for years, including 11 seminars and 19 cooking workshops in large cities.

Why Publish With Us

  • All the published articles are open access which means it’s free to access from anywhere in the world.
  • Each case published in this journal can improve health outcomes.
  • We offer fast publication while providing rigorous peer review to maintain the integrity of information.
  • Each article will be published under a Creative Commons license and authors are the copyright holder.
  • We are committed to the highest standards of peer review.
  • We’re proud of the impact and influence this journal have – from citations to social media shares.
  • We’re committed to promoting your work as widely as we can and providing as much visibility and exposure for your article as possible.

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Latest Papers

Author(s): Fujikawa T, Kato Y, Bando H*, Kakutani H, Kawata T, Yamamoto M, Wada K, Ishikura K, Shirai Y, Narutaki M, Matsuzaki S, Waka S
Abstract

Background: Recent diabetic treatments include Insulin Degludec/liraglutide (IDeg/Lira, Xultophy) in clinical practice. Authors have continued clinical research concerning diabetes, chronic renal failure, dialysis, and others.

Subjects and Methods: Ten patients with type 2 diabetes mellitus (T2DM) undergoing hemodialysis were investigated. They showed that ages 74.5 ± 5.9 years, M/F=6/4, BMI 21.1± 3.8kg/m2, hemodialysis duration 8.1± 5.7 years. At the beginning, fundamental data were Cre 8.2 ± 1.9 mg/dL, HbA1c 6.5 ± 0.8%. Xultophy was started on 5-12 doses and continued for 6 months with the same or 1-4 increased doses for better glycemic variability.

Results: Out of 10 subjects, the changes in HbA1c showed a decrease in 7, stable in 2, and an increase in 1. HbA1c value was 6.2 ± 0.8% in average at 6 months. There were no remarkable adverse effects by Xultophy for 6 months.

Discussion and Conclusion: Xultophy was started at 5-12 doses, which were remarkably lower doses than usual doses with satisfactory efficacy. One of the reasons may be from the characteristic of the patients, who were diabetic with undergoing hemodialysis. Another factor is possibly from liraglutide, which has hepatic clearance with potential vascular protective effects. These results are expected to become reference data for future research.

Abstract

Background: It is unclear whether metformin should be continued or discontinued in patients with coronavirus disease 2019 (COVID-19) admitted to the hospital.

Objective: To review metformin safety, particularly its impact on mortality among hospitalized patients with COVID-19.

Methods: Review of English literature by PUBMED search until September 11, 2020. Search terms included diabetes, COVID-19, metformin, Retrospective studies, meta-analyses, pertinent reviews, pre-print articles, and consensus guidelines are reviewed.

Results: Retrospective studies suggest that metformin use prior to hospital admission may be associated with decreased mortality in patients with diabetes admitted to the hospital with COVID-19. Continuing metformin use after hospital admission did not have a significant impact on 28-day all-cause mortality. Metformin use after hospitalization of patients with COVID-19 was associated with approximately 4.6 times increase risk of lactic acidosis in patients with severe symptoms of COVID-19, patients taking 2 gm/d of metformin or higher, and patients with estimated glomerular filtration rate (eGFR) less than 60 ml/min/1.73 kg/m2. Metformin use in the hospital was associated with a significant decrease in the risk of heart failure and acute respiratory distress syndrome (ARDS).

Conclusions: In patients with diabetes and COVID-19 admitted to the hospital, metformin should not be used in presence of severe symptoms of COVID-19, kidney dysfunction (eGFR < 60 ml/min/1.73 m2), and with daily doses of 2 gm or more due to increased risk of lactic acidosis.

Author(s): Silva AJL, Istilli PT, Teixeira CRS*, Lima RAD, Pereira MCA, Damasceno MMC, Garcia RAC, Calixto AAS
Abstract

This research aims to analyze income-related mortality by diabetes mellitus in a municipality inside the state of Sao Paulo, Brazil, from 2010 to 2014. It is about an ecological study and temporal tendency, it was analyzed, descriptively and spatially, the income-related deaths by diabetes mellitus from 2010 to 2014. There were 583 deaths, mostly (55.06%) in sex female. It highlights, the negative spatial relation between the incomes of up to two minimum wages per capita and mortality rate by diabetes mellitus (I= -0.13). The southern region was identified as a protection area (RR= 0.39; 95%CI= 0.29-0.54) for the occurrence of mortality by diabetes mellitus in both sexes. It is hoped that the findings in this study may foster and guide prevention strategies, and health care advance for the low-income groups and residents in risk areas.

Abstract

Objective: Liraglutide (LIRA), a Glucagon-like peptide-1 (GLP-1) receptor agonist, showed potential vascular protective effects with the mechanism remained incompletely understood. Therefore, this study aimed to investigate whether LIRA exerts its effect on vascular endothelial function in rats with type 2 diabetes mellitus (T2DM) via caveolin-1/ endothelial oxide synthase (eNOS) expression.

Methods: T2DM rats were used as study subjects and randomly divided into four groups: 1) Veh group, 2) Veh+LIRA group, 3) T2DM group, and 4) T2DM+LIRA group. All rats received either saline or LIRA 0.2 mg/kg (by i.p. injection) per day for 4 weeks. After the model was successfully established, vascular endothelial function was determined the effect of vasodilator to mesenteric artery rings. Immunofluorescence and western blot were performed to understand the molecular mechanism. Cultured HUVECs with small interfering RNA (siRNA) under high glucose (HG), NO concentration, and western blot were performed to understand the molecular mechanism between LIRA and vascular endothelial function.

Results: Based on our results, the LIRA reduced hyperglycemia and ameliorated vascular endothelial dysfunction in type 2 diabetic mice. LIRA activated eNOS phosphorylation, suppressing oxidative stress and enhancing endothelium-dependent vasorelaxation of mesenteric arteries. Besides, from its anti-oxidative capacity, LIRA activated eNOS to dilate the mesenteric arteries via the downregulation of Cav-1.

Conclusion: LIRA ameliorates vascular endothelial dysfunction in rats with type 2 diabetes mellitus via anti-oxidative and activated eNOS by downregulated Cav-1.

Abstract

This study aims to explore the possibility of the existence of dyslipidemia among prediabetics in India and to find the correlation if any, present between their glycated hemoglobin (HbA1c) levels and their lipid profile, and to identify the risk factor(s) if any, for the onset of diabetes. A cross-sectional study involving 212 individuals in Bangalore of Karnataka State, India from the period of August 2017 to February 2019 was considered for the study. Within the lipid profile, High-Density Lipoprotein (HDL) and the ratio of cholesterol to HDL displayed statistically significant differences between the means of the population of healthy nondiabetics and prediabetics. In prediabetics, HbA1c was negatively correlated with HDL. so, testing of HDL and cholesterol to HDL ratio at regular intervals for prediabetics should be made mandatory, as they fall in the risk category for developing type 2 Diabetes and this regular screening of HDL and Cholesterol to HDL ratio will prevent prediabetics from progressing into type2 diabetes later on. Regarding demographic factors, abdominal obesity was found to be statistically significantly associated with prediabetes. Hence prediabetics should follow a regular exercise regime to prevent themselves from progressing into diabetes in their later years.

Abstract

Authors and collaborators have continued clinical practice and research on diabetes for long, and begun Low Carbohydrate Diet (LCD) at first in Japan. We have proposed super-, standard-, petite-LCD methods with 12%, 26%, 40% of carbohydrate, and developed medical and social LCD movement by Japanese LCD promotion association (JLCDPA). For research protocol, subjects were 10 healthy young medical staff. Two tests were 75gOGTT and meal tolerance test (MTT) of breakfast of super-LCD with 300kcal and 6g of carbohydrate. Blood glucose and immunoreactive insulin (IRI) were measured at 0 min and 30 min. Results of glucose and IRI in median value (0-30min) showed as follows: i) OGTT; 89.5 mg/dL to 130.5 mg/dL, 5.1 μU/mL to 40.6 μU/mL, ii) MTT; 93.5 mg/dL to 84.5 mg/dL, 4.9μU/mL to 10.6 μU/mL (significant increase, p<0.05). The increments of IRI for GTT (carbo-75g) and MTT (carbo-6g) were analyzed. There was a significant correlation between increments of IRI in GTT and MTT (p<0.05). Blood glucose in MTT tended to decrease from 0 min to 30 min. These results suggested that insulin secretion would be sufficient and relatively excessive for 6g of carbohydrate amount.