Diagnosis of Thyroid Malignancy using Levels of Chemical Element Contents in Nodular Tissue | Abstract

Journal of Health Care and Research [ISSN: 2582-8967]

Journal of Health Care and Research [JHCR] [ISSN: 2582-8967]

ISSN: 2582-8967

Article Type: Original Article

DOI: 10.36502/2022/hcr.6207

J Health Care and Research. 2022 May 24;3(1):16-30

Vladimir Zaichick1*
1Radionuclide Diagnostics Department, Medical Radiological Research Centre, Obninsk, Russia

Corresponding Author: Prof. Dr. Vladimir Zaichick, PhD, DSc, CChem, FRSC ORCID iD
Address: Medical Radiological Research Centre, Korolyev St.4, Obninsk 249036, Kaluga Region, Russia.
Received date: 14 March 2022; Accepted date: 16 May 2022; Published date: 24 May 2022

Citation: Zaichick V. Diagnosis of Thyroid Malignancy using Levels of Chemical Element Contents in Nodular Tissue. J Health Care and Research. 2022 May 24;3(1):16-30.

Copyright © 2022 Zaichick V. This is an open-access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium provided the original work is properly cited.

Keywords: Diagnosis of Thyroid Malignancy, Normal Thyroid, Thyroid Nodules, Chemical Elements, Neutron Activation Analysis, Inductively Coupled Plasma Atomic Emission Spectrometry


Introduction: Thyroid benign (TBN) and malignant (TMN) nodules are a common thyroid lesion. The differentiation of TMN often remains a clinical challenge and further improvements of TMN diagnostic accuracy are warranted. The aim of present study was to evaluate possibilities of using differences in chemical elements (ChEs) contents in nodular tissue for diagnosis of thyroid malignancy.
Methods: Contents of ChEs such as aluminum (Al), boron (B), barium (Ba), calcium (Ca), chlorine (Cl), coper (Cu), iron (Fe), iodine (I), potassium (K), lithium (Li), magnesium (Mg), manganese (Mn), sodium (Na), phosphorus (P), sulfur (S), silicon (Si), strontium (Sr), vanadium (V), and zinc (Zn) were prospectively evaluated in “normal” thyroid (NT) of 105 individuals as well as in nodular tissue of thyroids with TBN (79 patients) and to TMN (41 patients). Measurements were performed using a combination of non-destructive and destructive methods: instrumental neutron activation analysis with high resolution spectrometry of short-lived radionuclides and inductively coupled plasma atomic emission spectrometry.
Results: It was observed that in TMN tissue the mean mass fraction of I was lower while the mean mass fractions of K, Mg, and P were higher than in both NT and TBN groups of samples. It was demonstrated that I content is nodular tissue is the most informative parameter for the diagnosis of thyroid malignancy. It was found that “Sensitivity”, “Specificity” and “Accuracy” of TMN identification using the I level in the needle biopsy of affected thyroid tissue was significantly higher than that using US examination and cytological test of fine needle aspiration biopsy.
Conclusions: It was concluded that determination of the I level in a needle biopsy of TNs using non-destructive instrumental analytical method is a fast, reliable, and very informative diagnostic tool that can be successfully used as an additional test of thyroid malignancy identification.


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