ARTICLES IN PRESS | YEAR-2026 | VOLUME-7

Backgrounds: Skin cancer (SC) and skin aging (SA) are polygenic phenotypes posing significant health risks. While molecular biomarkers and related pathways for each have been studied separately, shared mechanisms remain unclear. This study aimed to identify shared biomarkers and mechanisms between SC and SA using gene expression profiling, offering new insights for future research. This study identified shared differentially expressed genes (DEGs) of the two phenotypes, their related important pathways, and interactions between significant functional proteins.
Method: DEGs of SA and SC were identified via LIMMA analysis based on mRNA datasets from the Gene Expression Omnibus and ArrayExpress databases. Pathway enrichment analysis was conducted using the overrepresentation method to identify shared DEGs-associated KEGG pathways and GO terms. Using Cytoscape, protein-protein interaction (PPI) networks were constructed based on the STRING database. Core networks and top functional genes were identified using the MCODE plugin and CytoHubba plugin.
Results: Results showed SPRR1A and S100A2 as significant shared DEGs (GSE85358: P_SPRR1A = 0.0028, logFC_SPRR1A = -0.93; P_S100A2 = 0.0086, logFCS100A2 = -0.60; GSE2503: P_SPRR1A = 0.0089, logFC_SPRR1A = 2.5; P _S100A2 = 1.5, logFC_S100A2 = 0.0095; GSE3189: P_SPRR1A = 1.7E-07, logFC_SPRR1A = -3.4; P_S100A2 = 1.0E-14, logFC_S100A2 = -4.5). Those shared genes enriched in immune response, endothelial cell migration, cellular process, and peptide cross-linking. In PPI analysis, top hub genes of networks were PIK3R1, NANOG, VAV3, SMTN, SPRR1B, MET, MYLK, EPCAM, SPRR1A, and GATA3.
Conclusions: Our findings elucidate shared genetic architectures between SC and SA. The identification of shared genes and protein-protein interaction networks associated with both SA and SC suggests an underlying molecular genetic mechanism, offering opportunities to develop therapeutic strategies against SA and SC comorbidity.

Carbohydrates are defined as “sugars + dietary fiber,” and dietary fiber has been considered indigestible and therefore provides no energy (0 kcal/g). Much dietary fiber is fermented by intestinal bacteria to produce short-chain fatty acids (SCFAs) such as acetic acid, propionic acid, and butyric acid. These SCFAs are partially absorbed by the host and used for metabolic energy, so dietary fiber contains “available energy”. Consequently, dietary fiber is generally classified into 3 groups and converted into energy equivalents, which are non-absorbed fibers as 0 kcal/g, partially fermented fibers as 1 kcal/g, and fairly completely fermented fibers as 2 kcal/g.

Recent trends for psychology, art therapy, and artificial intelligence (AI) would be described with some perspectives. Art therapy support using generative AI has attracted attention. Clinical introduction of AI offers various new benefits and creative possibilities, such as expanding the diversity of expression, enabling the quantification of various factors through automated analysis, and improving access. The impact of AI-generated images shows clients’ projective/transference relationships, their effects on self-efficacy/intrinsic motivation, and the amplification of bias in therapists’ clinical judgments. Integrated approach would be required, where a balance is maintained between the core elements of subjectivity of expression and the therapeutic relationship.

Objective: To understand the prevalence rate of fatty liver among employees of a power plant in Wuhu City and analyze its influencing factors.
Methods: The health examination results of 1,818 employees of a power plant in Wuhu City with complete data in 2015 were collected and statistically analyzed.
Results: A total of 691 cases of fatty liver were detected with a prevalence rate of 38.01%. Among them, there were 499 male cases with a prevalence rate of 43.77%. There were 192 female cases with a prevalence rate of 28.32%. There was a statistically significant comparison of the prevalence of fatty liver between men and women (p<0.01). The prevalence of fatty liver in men is 1.55 times that in women. The prevalence of fatty liver increases with age (p<0.01). The prevalence of fatty liver in men before the age of 60 was significantly higher than that in women (p<0.01). The prevalence of fatty liver in women was higher than that in men after the age of 60 (p>0.05). The prevalence rates of overweight and obesity, hyperglycemia, hypertension, hyperlipidemia, hyperuricemia, gallbladder diseases, and abnormal liver function in the fatty liver group were significantly higher than those in the non-fatty liver group (p<0.01). The prevalence of abnormal electrocardiogram in the fatty liver group was significantly lower than that in the non-fatty liver group (p<0.01). The levels of age, body mass index (BMI), fasting blood glucose (FBG), systolic blood pressure (SBP), diastolic blood pressure (DBP), total cholesterol (TC), triglycerides (TG), low-density lipoprotein cholesterol (LDL-C), and uric acid (UA) in the fatty liver group were significantly higher than those in the non-fatty liver group (p<0.05). The high-density lipoprotein cholesterol (HDL-C) in the fatty liver group was significantly lower than that in the non-fatty liver group (p<0.001).
Conclusion: The prevalence of fatty liver among employees in a power plant in Wuhu City is relatively high. Body mass index, blood lipid, blood pressure, blood sugar, and blood uric acid levels are closely related to the occurrence of fatty liver. Losing weight, controlling high blood lipid, and maintaining normal blood sugar, blood pressure, and blood uric acid levels are important measures for the prevention and treatment of fatty liver.

Background: This study assessed the health and nutritional services available to households in South and East Darfur States, with a focus on maternal and newborn child health services, infant and young child feeding practices, and overall nutritional status.
Methods: A cross-sectional quantitative approach was utilized for data collection, including household surveys. A total of 1,285 households participated in the study, and a nutrition assessment was conducted on 1,374 children aged 6–59 months.
Results: Access to healthcare services remains a significant challenge in South and East Darfur, where over 80.0% (80.9% SD, 80.9% ED) of households reported difficulties in obtaining the necessary healthcare services. Statistics revealed that only 25.2% (28.4% SD, 21.9% ED) gave birth at a health facility, highlighting the challenging maternal healthcare gaps. Vaccination rates also demonstrate disparities; while BCG coverage reached 59.4% (44.1% SD, 74.6% ED), polio dose O at birth vaccination coverage stood at 65.6% (52.5% SD, 78.6% ED). Childhood illness management through Integrated Community Case Management (iCCM) revealed alarming prevalence rates of malaria (43.9% [48.9% SD, 38.9% ED]), while 39.1% (49.8% SD, 28.3% ED) had ARI, with only 53.3% (63.0% SD, 43.6% ED) able to seek and access proper treatment/management. Furthermore, malnutrition rates were critical, with Global Acute Malnutrition at 19.9% in South Darfur and 15.5% in East Darfur. Stunting was prevalent in 36.6% of children aged 6–59 months in South Darfur, emphasizing the dire health and nutrition situation.
Conclusions: Overall, the findings underscore the urgent need for targeted interventions to improve access to healthcare services, address healthcare-seeking behaviors, and enhance nutrition practices and service delivery in South and East Darfur. Efforts should be made to strengthen nutrition programs and support caregivers in promoting optimal health and nutrition for their children.