Asploro Journal of Biomedical and Clinical Case Reports

Asploro Journal of Biomedical and Clinical Case Reports

Takafumi Kawata¹, Hiroshi Bando^1,2,3iD*, Yoshinobu Kato¹, Hisako Yamashita¹, Yoshikane Kato¹, Katsunori Ogura^1
1Kanaiso Hospital, Tokushima, Japan
²Medical Research/Tokushima University, Tokushima, Japan
³Japan Low Carbohydrate Diet Promotion Association (JLCDPA), Kyoto, Japan

Corresponding Author: Hiroshi Bando ^{ORCID iD}
Address: Tokushima University /Medical Research, Nakashowa 1-61, Tokushima 770-0943, Japan.
Received date: 31 December 2023; Accepted date: 15 January 2024; Published date: 20 January 2024

Citation: Kawata T, Bando H, Kato Y, Yamashita H, Kato Y, Ogura K. Improvement of HbA1c, Weight and Fatty Liver by Short Treatment of Imeglimin (Twymeeg). Asp Biomed Clin Case Rep. 2024 Jan 20;7(1):30-35.

Copyright © 2024 Kawata T, Bando H, Kato Y, Yamashita H, Kato Y, Ogura K. This is an open-access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium provided the original work is properly cited.

Keywords: Type 2 Diabetes, imeglimin, Twymeeg, Low Carbohydrate Diet, Japan LCD Promotion Association, Trials of IMeglimin for Efficacy and Safety

Abbreviations: T2D: Type 2 Diabetes; LCD: Low Carbohydrate Diet; JLCDPA: Japan LCD Promotion Association; TIMES: Trials of IMeglimin for Efficacy and Safety

Abstract

The patient is a 55-year-old male with type 2 diabetes (T2D). In his 20s, 30s, and 50s, his body weight was 80 kg, 95 kg, and 90 kg, respectively. HbA1c was 10.9% in March 2023, and he was prescribed imeglimin (Twymeeg) as an oral hypoglycemic agent (OHA). HbA1c decreased to 9.3%, 7.2%, and 6.8% within just 3 months. His body weight also decreased from 86 kg to 82 kg during this period. Liver function tests showed improvement between March and May 2023, with AST decreasing from 54 to 24 U/L, ALT from 121 to 28 U/L, and GGT from 45 to 18 U/L, respectively. This suggests an improvement in fatty liver.