The current study revealed a dramatic explosive outbreak of N Corona-virus 2019 infection in terms of several confirmed cases, several deaths and number of countries affected with the outbreak within 50 days, the explosion of the epidemic with high morbidity and mortality incidences reflected another nature of the diseases which is the aggressiveness of the virus. Both the explosiveness and the aggressiveness nature of the epidemic alarming global as well as national health care systems in regards of responsiveness capacity, containment strategies and applying effective transmission chain break down strategies, the nature of the current epidemic reflected the fragile status of global capacity of health system response along with lack of preparedness and un ability of prediction and forecasting. Furthermore, the current epidemic is taking new trend, moving from localized area to worldwide zones which make containment much harder and needs more efforts at the level of global mobility, which may push toward more economical loss. The other significant observation in the current pandemic is, that we did not reach yet to the peak of the explosion, and there will be further potentials of the epidemic that can be expressed in the coming days and months until it reaches to the peak and decline down.

The symptoms of this novel pneumonia were also non-specific. With patient have other comorbidities had more severe systemic symptoms of generalized weakness and dry cough. As expected, they might have decreased total white blood cell, lymphocyte, or platelet counts, with also extended activated thromboplastin time and increased C-reactive protein level. The multifocal ground-glass changes on lung CT scans were typical of viral pneumonia. Their lung involvement was also more diffuse and extensive than those of the younger patients, whose blood test results were largely normal. The patient, who had a history of chronic sinusitis, might have a bacterial superinfection because he had a productive cough instead of a dry cough. He also had a high white blood cell count, although the bacterial test was negative [14-20].

An outbreak of novel coronavirus is ongoing at Wuhan in the winter of 2019–20. Similar to the 2003 SARS outbreak in Guangzhou, Wuhan is also a rapidly flourishing capital city of the Hubei province and the traffic hub of central China. Moreover, both outbreaks were initially connected to wet markets where game animals and meat were sold. In the case of SARS, the person-to-person transmission was efficient and super-spreading events had led to major outbreaks in hotels and hospitals. Learning from the SARS outbreak, which started as animal-to-human transmission during the first phase of the epidemic, all game meat trades should be optimally regulated to terminate this portal of transmission. But as shown in this study, it is still crucial to isolate patients and trace and quarantine contacts as early as possible because asymptomatic infection appears possible (as shown in one of our patients), educate the public on both food and personal hygiene, and alert health-care workers on compliance to infection control to prevent super-spreading events. Unlike the 2003 SARS outbreak, the improved surveillance network and laboratory capability of China was able to recognize this outbreak within a few weeks and announced the virus genome sequences that would allow the development of rapid diagnostic tests and efficient epidemiological control. Our study showed that person-to-person transmission in family homes or hospitals, and intercity spread of this novel coronavirus are possible and therefore vigilant control measures are warranted at this early stage of the epidemic [20-25].