Journal of Health Care and Research
Article Type: Commentary
J Health Care and Research. 2020 Jun 27;1(2):101-04
Corresponding Author: Hiroshi BANDO, MD. PhD, FACP ORCID ID
Address: Medical Research/Tokushima University, Nakashowa 1-61, Tokushima 770-0943, Japan.
Received date: 25 May 2020; Accepted date: 18 June 2020; Published date: 27 June 2020
Citation: Bando H, Kato Y. Relationship among Frailty, Muscle Volume, Protein Intake in Patients with Chronic Kidney Disease (CKD). J Health Care and Research. 2020 Jun 27;1(2):101-04.
Copyright © 2020 Bando H, Kato Y. This is an open-access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Keywords: Frailty, Sarcopenia, Renal Hyperfiltration (RHF), Glomerular Filtration Rate (GFR), Chronic Kidney Disease (CKD), Myofibrillar Protein Synthesis (MPS)
Maintenance of muscle mass and protein intake are closely related. Insufficient protein intake in each meal or a total of three meals causes a decrease in muscle mass. For the elderly, protein intake has been insufficient at breakfast and then a large amount of protein is necessary for stimulating muscle protein synthesis. Consequently, there is a need to more actively and consciously take protein in older age. There have been conflicting results concerning the effect of protein restriction diet on glomerular filtration rate (GFR) in patients with chronic kidney disease (CKD) from the data of various meta-analyses. A beneficial effect and also no significant effect was found. One of the perspectives suggested that protein restriction diet may make slower CKD progression in T1DM and non-DM subjects, but not for T2DM patients. However, further studies will be necessary in the future.