Analysis of Structure, Mechanism of Action and Efficacy of Potential and Ideal COVID-19 Treatments | Abstract

Journal of Health Care and Research

Journal of Health Care and Research

Article Type: Literature Review

DOI: 10.36502/2020/hcr.6179

J Health Care and Research. 2020 Nov 21;1(3):197-208

Halim M1*, Halim A2, Trivosa V3
1University of Salford, MSc Biomedical Science, Greater Manchester, United Kingdom
2Zhong Shan Hospital, Shanghai Medical College, Fudan University, Shanghai, China
3Hospital of Stomatology, Wuhan University, Wuhan, China

Corresponding Author: Michael Halim
Address: University of Salford, MSc Biomedical Science, Greater Manchester, United Kingdom.
Received date: 24 September 2020; Accepted date: 13 November 2020; Published date: 21 November 2020

Citation: Halim M, Halim A, Trivosa V. Analysis of Structure, Mechanism of Action and Efficacy of Potential and Ideal COVID-19 Treatments. J Health Care and Research. 2020 Nov 21;1(3):197-208.

Copyright © 2020 Halim M, Halim A, Trivosa V. This is an open-access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Keywords: Lopinavir, COVID-19, Ritonavir, SARS-CoV-2, Chloroquine, Remdesivir, Favipiravir, Arbidol, hydroxychloroquine

Abstract

Introduction: Covid-19 has a positive-stranded RNA, which is characterised by protruding spikes that enhance replication.
Objective: To offer detailed information on treatment approaches that are applied in preventing Covid-19.
Methods: Information was obtained from PubMed and CINAHL. SPSS and Microsoft Excel were used to analyse the data and graph it accordingly.
Results: There are many treatments such as chloroquine and hydroxychloroquine, RDV, Lopinavir or Ritonavir, and Arbidol combined with Favipiravir. On analysing the structures and mechanisms, RDV indicated better secondary and primary outcomes, including early clearance of the viral load and reduced hospital stay. Chloroquine and hydroxychloroquine were found to be efficacious in vitro; however, their effectiveness in vitro declined due to adverse outcomes.
Conclusion: Due to the repurposing of the drugs described, it is important to combine treatments to control Covid-19 while developing vaccines. There is a need for further extensive research on huge samples to establish the efficiency of specific therapies and treatments.

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