Diabetes Research: Open Access
Hiroshi Bando1,2iD*
1Medical Research/Tokushima University, Tokushima, Japan
2Japan Low Carbohydrate Diet Promotion Association (JLCDPA), Kyoto, Japan
Corresponding Author: Hiroshi Bando ORCID iD
Address: Tokushima University /Medical Research, Nakashowa 1-61, Tokushima 770-0943, Japan.
Received date: 28 April 2024; Accepted date: 13 May 2024; Published date: 20 May 2024
Citation: Bando H. Developing Research for Five Subtypes of Diabetes with Specific Characteristics. Diab Res Open Access. 2024 May 20;5(1):09-12.
Copyright © 2024 Bando H. This is an open-access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium provided the original work is properly cited.
Keywords: Diabetes Subtypes, Cluster Analysis, Adult-Onset Diabetes, Outcome Reduction with an Initial Glargine Intervention, Mild Age-Related Diabetes
Abbreviations: ORIGIN: Outcome Reduction with an Initial Glargine Intervention; MARD: Mild Age-Related Diabetes
Abstract
Recently, sub-classifications for adult-onset diabetes have been presented based on cluster analysis. There are 5 exclusive subtypes, with clusters ranging from 1 to 5: severe autoimmune diabetes (SAID), severe insulin-deficient diabetes (SIDD), severe insulin-resistant diabetes (SIRD), mild obesity-related diabetes (MOD), and mild age-related diabetes (MARD), respectively. The related variables known include GAD antibody, age at diagnosis, BMI, HbA1c, and HOMA2-B and HOMA2-IR. From the Outcome Reduction with an Initial Glargine Intervention (ORIGIN) trial, the numerical numbers of the 5 subtypes are 241-1594-914-1595-2673, respectively. The prevalence percentages for the 5 subtypes in 3 countries are as follows: Japan: 5.4-19.0-7.2-28.9-39.5, Germany: 22.0-3.0-11.0-29.0-35.0, and Finland: 9.9-8.9-11.2-22.8-47.3, respectively.
