Diabetes Research: Open Access
Article Type: Original Article
Diab Res Open Access. 2020 Jun 12;2(2):31-37
Ebe K1,2, Hashimoto M1,2, Bando H2,3*, Bando M2,4, Muneta T2,5
1Takao Hospital, Kyoto, Japan
2Japan Low Carbohydrate Diet Promotion Association, Kyoto, Japan
3Medical Research/Tokushima University, Tokushima, Japan
4Department of Gastroenterology and Oncology, Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima, Japan
5Muneta Maternity Clinic, Chiba, Japan
Corresponding Author: Hiroshi BANDO, MD. PhD, FACP ORCID ID
Address: Medical Research/Tokushima University, Nakashowa 1-61, Tokushima 770-0943, Japan.
Received date: 15 May 2020; Accepted date: 03 June 2020; Published date: 12 June 2020
Citation: Ebe K, Hashimoto M, Bando H, Bando M, Muneta T. Proposal of Meal Tolerance Test (MTT) For Investigating Ability of Insulin Secretion for Small Carbohydrate Load. Diab Res Open Access. 2020 Jun 12;2(2):31-37.
Copyright © 2020 Ebe K, Hashimoto M, Bando H, Bando M, Muneta T. This is an open-access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Keywords: Low Carbohydrate Diet (LCD), Japanese LCD Promotion Association (JLCDPA), Meal Tolerance Test (MTT), Super-LCD Glycemic Index (GI)
Abbreviations: LCD: Low Carbohydrate Diet, JLCDPA: Japanese LCD Promotion Association, MTT: Meal Tolerance Test, IRI: Immunoreactive Insulin, OGTT: Oral Glucose Tolerance Test, GI: Glycemic Index
Authors and collaborators have continued clinical practice and research on diabetes for long, and begun Low Carbohydrate Diet (LCD) at first in Japan. We have proposed super-, standard-, petite-LCD methods with 12%, 26%, 40% of carbohydrate, and developed medical and social LCD movement by Japanese LCD promotion association (JLCDPA). For research protocol, subjects were 10 healthy young medical staff. Two tests were 75gOGTT and meal tolerance test (MTT) of breakfast of super-LCD with 300kcal and 6g of carbohydrate. Blood glucose and immunoreactive insulin (IRI) were measured at 0 min and 30 min. Results of glucose and IRI in median value (0-30min) showed as follows: i) OGTT; 89.5 mg/dL to 130.5 mg/dL, 5.1 μU/mL to 40.6 μU/mL, ii) MTT; 93.5 mg/dL to 84.5 mg/dL, 4.9μU/mL to 10.6 μU/mL (significant increase, p<0.05). The increments of IRI for GTT (carbo-75g) and MTT (carbo-6g) were analyzed. There was a significant correlation between increments of IRI in GTT and MTT (p<0.05). Blood glucose in MTT tended to decrease from 0 min to 30 min. These results suggested that insulin secretion would be sufficient and relatively excessive for 6g of carbohydrate amount.