Staphylococcus aureus is often responsible for late septic infections, more rarely of toxic ones, occurring in neonatal period [2,3]. Although bullous impetigo and SSSS are considered as a spectrum of disease caused by staphylococcus aureus induced exfoliative toxins, they have distinct differences [2,3]. In bullous impetigo, the exfoliative toxins are restricted to the area of infection, and bacteria can be cultured from the blister contents. In staphylococcal scalded skin syndrome the exfoliative toxins are spread hematogenously from a localized source causing widespread epidermal damage at distant sites [4,5]. The lesions of bullous impetigo are commonly seen on the face, trunk and extremities which are vesicles to begin with and later becoming pus-filled, followed by rupture and crusting. The lesional bacterial culture reveals S. aureus. Nikolsky’s sign, a disruption of normal skin caused by mechanical stress, is negative. In SSSS The diagnosis is mainly clinical, based on the findings of tender erythroderma, bullae, and desquamation with a scalded appearance especially in friction zones, periorificial scabs/crusting, positive Nikolsky sign, and absence of mucosal involvement [4,5]. The diagnosis can be confirmed by culturing S.aureus from any suspected primary focus of infection, but A skin biopsy is usually not necessary, but if performed, may show superficial intraepidermal separation along the granular cell layer [6,7]. In our patient, bullous impetigo was characterized by isolation of S.aureus and by histological findings. However, there was no case of extensive bullous impetigo followed by SSSS in neonates, as far as we know. Once SSSS is diagnosed, the treatment consists of supportive care and eradication of the primary infection with anti-staphylococcal antibiotics administered by vein for a minimum of seven days [8]. Bullous impetigo and staphylococcal scalded skin syndrome have a different prognosis.