Asploro Journal of Biomedical and Clinical Case Reports
Article Type: Case Report
Asp Biomed Clin Case Rep. 2020 Aug 15;3(2):171-77
Silva LFF1, Martins MC1, Caplum MC1, Luz MS1, Amaral VM1, de Souza VA1, de Souza HD2,3,4, Silva ALM6, Panconi CR2,3,4,5, Zimmermmann JB2,3,4,5*
1Gynecology and Obstetrics Service, Barbacena School of Medicine (FUNJOBE), Barbacena, Minas Gerais State, Brazil
2Medical School of Federal University of Juiz de Fora, Juiz de Fora, Minas Gerais State, Brazil
3Healthcare Center of the University Hospital, Medical School of Federal University of Juiz de Fora, Obstetrics service, Brazil
4High-Risk Prenatal Care, Brazil
5Zimmermmann Obstetrics and Gynecology Clinic, Brazil
6Anesthesiology and Acupuncture Clinic, Brazil
Corresponding Author: Juliana Barroso Zimmermmann ORCID ID
Address: Gynecology and Obstetrics Service, Barbacena School of Medicine (FUNJOBE), Barbacena, Minas Gerais State, Brazil.
Received date: 27 June 2020; Accepted date: 03 August 2020; Published date: 15 August 2020
Citation: Silva LFF, Martins MC, Caplum MC, Luz MS, Amaral VM, de Souza VA, de Souza HD, Silva ALM, Panconi CR, Zimmermmann JB. Myasthenia Gravis in Pregnancy Treated With Daily Massive Vitamin D Dose. Asp Biomed Clin Case Rep. 2020 Aug 15;3(2):171-77.
Copyright © 2020 Silva LFF, Martins MC, Caplum MC, Luz MS, Amaral VM, de Souza VA, de Souza HD, Silva ALM, Panconi CR, Zimmermmann JB. This is an open-access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium provided the original work is properly cited.
Keywords: Myasthenia gravis, Autoimmune, Vitamin D, Asthenia, Fatigue
Myasthenia gravis (MG) is an autoimmune disease affecting the motor endplate of striated muscle. It is caused by antibodies that act in the cholinergic receptors at the post-synaptic portion of the neuromuscular junction, which results in asthenia and fatigue in some muscle groups. In pregnancy, it’s unpredictable, because pregnant women can present MG exacerbation, remission, stability, or even a myasthenic crisis during pregnancy. Complications are more frequent in the first trimester of pregnancy and the first 30 days of puerperium. Vitamin D and its metabolites are potent immunomodulators since their immuno-regulatory effect directly inhibits effector T cells and induces regulatory T cells (Treg) to decrease the production of inflammatory cytokines. The authors present a case report of a patient with MG who was treated throughout pregnancy with massive doses of vitamin D, obtaining good results.