Asploro Journal of Biomedical and Clinical Case Reports

Asploro Journal of Biomedical and Clinical Case Reports

An-Phuc Ta^1iD*, Megan Hsu^1iD*, Satori Iwamoto^1
1California Northstate University College of Medicine, USA

Corresponding Author: An-Phuc Ta ^{ORCID iD} and Megan Hsu ^{ORCID iD}
Address: College of Medicine, California Northstate University, 9700 West Taron Drive, Elk Grove, California 95757, USA.
Received date: 03 November 2023; Accepted date: 24 November 2023; Published date: 30 November 2023

Citation: Ta AP, Hsu M, Iwamoto S. Li-Fraumeni Syndrome Cancer Surveillance Strategy Considerations for Glioblastoma Multiforme. Asp Biomed Clin Case Rep. 2023 Nov 30;7(1):10-13.

Copyright © 2023 Ta AP, Hsu M, Iwamoto S. This is an open-access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium provided the original work is properly cited.

Keywords: Li-Fraumeni Syndrome, Glioblastoma Multiforme, Cancer Surveillance, Toronto Protocol, Brain MRI

Abstract

Sporadic or inherited deficiencies in the production or activity of the tumor suppressor P53 lead to Li-Fraumeni Syndrome (LFS), a multi-organ tumorigenic condition. Glioblastoma multiforme (GBM), a tumor that commonly presents with a median age of 64, has a higher chance of appearing in much younger patients who have LFS [9]. Since the implementation of the 2016 Toronto Protocol to increase cancer surveillance in LFS patients, three cases of LFS-GBM have been discussed [11-13]. Here, we report a case of LFS in an 18-year-old male who had a seizure due to a GBM that had evaded a full-body MRI six months prior. Furthermore, we discuss the potential quality of life (QOL) benefits of providing patients with a shorter brain MRI screening interval: better survival outcomes and peace of mind. Though there may be a rise in the financial cost with an increase in the number of MRI scans, the prevalence of aggressive tumors that must be treated early for a better prognosis warrants more frequent screening. Furthermore, we address the importance of expanding clinical knowledge on GBM in the LFS setting as well as addressing the benefits of the protocol through statistical studies.