Asploro Journal of Biomedical and Clinical Case Reports

Asploro Journal of Biomedical and Clinical Case Reports

Zou Qian^1*
1West China Hospital, West China School of Medicine, Sichuan University, Chengdu, China

Corresponding Author: Zou Qian
Address: Sichuan University West China Hospital, 37 Guoxuexiang, Chengdu, Sichuan, 610041 China.
Received date: 21 September 2024; Accepted date: 04 November 2024; Published date: 11 November 2024

Citation: Qian Z. Hydromorphone Combined with Ropivacaine for Caudal Block Reduce Early Postoperative Pain in Children: A Randomized Clinical Trial. Asp Biomed Clin Case Rep. 2024 Nov 11;7(3):278-87.

Copyright © 2024 Qian Z. This is an open-access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium provided the original work is properly cited.

Keywords: Hydromorphone, Caudal Block, Children, Postoperative Analgesia

Abstract

Purpose: This prospective, randomized, double-blinded study aimed to evaluate the effectiveness and safety of hydromorphone combined with ropivacaine for caudal block in children.
Patients and Methods: One hundred children scheduled to undergo hypospadias repair or congenital hip arthroplasty at West China Hospital were included. The patients were randomly allocated into the HR group (hydromorphone combined with ropivacaine) or the R group (ropivacaine only). In the HR group, patients received a single-shot caudal block with hydromorphone 10 μg/kg combined with 0.2% ropivacaine 1 ml/kg. In the R group, only 0.2% ropivacaine 1 ml/kg was administered for the single-shot caudal block. The primary outcome was the postoperative pain score for the first 72 hours in both groups.
Results: A total of 106 eligible children were screened, and 100 were included in this trial, with 50 in the HR group and 50 in the R group. The average postoperative FLACC pain score within 12 hours after surgery was significantly lower in the HR group compared to the R group (P < 0.05). The pain scores at 1 h, 6 h, and 12 h post-surgery in the HR group were significantly lower than those in the R group (P < 0.05). The incidence of moderate-to-severe pain in the HR group was markedly lower than that in the R group (P < 0.05).
Conclusion: The use of hydromorphone 10 μg/kg combined with 0.2% ropivacaine for single-shot caudal block in children can effectively reduce early postoperative pain scores and the incidence of moderate-to-severe pain. No adverse reactions were noted from hydromorphone, except pruritus.