Asploro Journal of Biomedical and Clinical Case Reports
Article Type: Original Article
Asp Biomed Clin Case Rep. 2020 Dec 22;3(3):241-56
Jain R1, Javeri Y2, Nasa P3*, Kashyap R4, Khanna AK5, Tayar AA6, Bhaskar B7, Jagiasi BG8, Juneja D9, Lipman J10,11, Ng J12, Portilla JLP13, Zirpe K14, Popugaev KA15, Hashmi M16, Malbrain MLNG17,18, Kirkman MA19, Chan MTV20, Turkoglu M21, Mer M22, Singer M23, Harriss M24, Rangappa P25, Piacevoli Q26,27,28,29,30, Mani RK31, Mishra RC32, Garg R33, Yadav R34, Bagdia S35, Donovan S36, Reza ST37, Yeh TY38,39,40,41, Videtta W42
1Consultant Critical Care, Nayati Healthcare, Mathura, Uttar Pradesh, India
2Head CCM and Emergency Medicine, Regency Super Specialty Hospital, Lucknow, India
3Specialist and Head Critical Care Medicine, Head -Prevention and Control of Infection, NMC Specialty Hospital, Al Nahda 2, Dubai, UAE
4Assistant Professor of Anesthesiology, Department Of Anesthesia and Critical Care Medicine, Mayo Clinic, USA
5Associate Professor, Section Head for Research, Department of Anesthesiology, Wake Forest University School of Medicine, Cleveland, OH, USA
6Consultant, Head of ICU at Security Forces Hospital, Dammam, Saudi Arabia
7Director of the Intensive Care Services, Chair Intensive Care Committee, American Hospital Dubai, UAE
8Head of Critical Care Department, Reliance Hospital, Navi Mumbai, India
9Associate Director, Institute of Critical Care Medicine, Max Super Specialty Hospital, Saket New Delhi, India
10The University of Queensland, Australia
11Scientific Consultant, Nimes University Hospital, University of Montpellier, France
12Department of Anaesthesiology, Intensive Care and Pain Medicine, Tan Tock Seng Hospital, Singapore
13Medicina Intensiva, Coordinador Neuro UCIN, Jefe del Servicio de Cuidados Intermedios, Hospital Nacional Almanzor Aguinaga Asenjo, EsSalud, Perú
14Prof and Head of Department Neuro Intensive Care Unit, Ruby Hall Clinic, Grant medical Foundation, Pune, India
15Deputy Director, Head of Regional Vascular Centre, Sklifosovsky Research Institute of Emergency Medicine, Bolshaya Sukharevskaya Square, Russia
16Professor and Head of Department, Critical Care Medicine, Ziauddin University, Karachi, Pakistan
17Department Intensive Care Medicine, University Hospital Brussel (UZB), Brussels, Belgium
18Faculty of Medicine and Pharmacy, Vrije Universiteit Brussel (VUB), Brussels, Belgium
19Atkinson Morley Regional Neurosciences Centre, St George’s Hospital, London, UK
20Professor, Department of Anaesthesia and Intensive Care, The Chinese University of Hong Kong, Hong Kong Special Administrative Region, China
21Associate Professor, Department of Internal Medicine, Medical İntensive Care Unit, Gazi University Faculty of Medicine, Turkey
22Clinical Head Adult Multidisciplinary Intensive Care Unit, Department of Medicine, Divisions of Critical Care and Pulmonology, University of the Witwatersrand, Johannesburg, South Africa
23Professor of Intensive Care Medicine, Director, Bloomsbury Institute of Intensive Care Medicine, Division of Medicine, University College London, London, UK
24Pulmonologist, Medcare Hospital Sharjah and Dubai London Clinic and Hospital, Dubai, UAE
25Consultant Intensive Care Physician, Columbia Asia Hospitals, Bangalore, India
26Professor and Head Department of Anaesthesia and Intensive Care, Rome, Italy
27Member of the Board of the FEDERATION EUROPEEN des MEDICINE, Brussels, Belgium
28P. Member of the World Commission on Safety and Quality WFSA, WHO
29Visiting Professor, Ss. Cyril and Methodius University in Skopje, Republic of North Macedonia, Greece
30Visiting Professor, Campus Bio Medico University, Rome, Italy
31Director, Strategy and COVID-19 Management, Yashoda Super Specialty Hospital, Kaushambi, Ghaziabad, UP, India
32Honorary Consultant Intensivist & Internist, Ahmedabad, India
33Additional Professor of Anaesthesiology, Critical Care, Pain and Palliative Medicine, All India Institute of Medical Sciences, New Delhi, India
34Senior Consultant Critical Care Medicine, Nayati Healthcare, Mathura, UP, India
35Pulmonologist, NMC Royal Hospital DIP, Dubai, UAE
36Clinical Professor of Medicine, UCLA School of Medicine, USA
37Assistant Professor, Critical Care Medicine, Dhaka Medical College Hospital, Dhaka, Bangladesh
38Clinical Associate Professor, Attending Anesthesiologist and Intensivist, Department of Anesthesiology, National Taiwan University Hospital (NTUH), Taiwan
39Chair, Scientific Committee, Taiwan Society of Emergency & Critical Care Medicine (TSECCM), Taiwan
40Vice-Chair, Research Committee and International Affairs, TSECCM, Taiwan
41Secretary General, Taiwan Society of Critical Care Medicine (TSCCM), Taiwan
42Hospital Posadas, Buenos Aires, Argentina
Corresponding Author: Prashant Nasa, MD ORCID ID
Address: Specialist and Head Critical Care Medicine, Head -Prevention and Control of Infection, NMC Specialty Hospital, Al Nahda 2, Dubai, UAE.
Received date: 19 November 2020; Accepted date: 14 December 2020; Published date: 22 December 2020
Citation: Jain R, Javeri Y, Nasa P, Kashyap R, Khanna AK, Tayar AA, Bhaskar B, Jagiasi BG, Juneja D, Lipman J, Ng J, Portilla JLP, Zirpe K, Popugaev KA, Hashmi M, Malbrain MLNG, Kirkman MA, Chan MTV, Turkoglu M, Mer M, Singer M, Harriss M, Rangappa P, Piacevoli Q, Mani RK, Mishra RC, Garg R, Yadav R, Bagdia S, Donovan S, Reza ST, Yeh TY, Videtta W. Consensus Statement for Pharmacological Management of Coronavirus Disease 2019 (COVID-19): A Pragmatic Approach. Asp Biomed Clin Case Rep. 2020 Dec 22;3(3):241-56.
Copyright © 2020 Jain R, Javeri Y, Nasa P, Kashyap R, Khanna AK, Tayar AA, Bhaskar B, Jagiasi BG, Juneja D, Lipman J, Ng J, Portilla JLP, Zirpe K, Popugaev KA, Hashmi M, Malbrain MLNG, Kirkman MA, Chan MTV, Turkoglu M, Mer M, Singer M, Harriss M, Rangappa P, Piacevoli Q, Mani RK, Mishra RC, Garg R, Yadav R, Bagdia S, Donovan S, Reza ST, Yeh TY, Videtta W. This is an open-access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium provided the original work is properly cited.
Keywords: Consensus Statement, COVID-19, Modified Delphi Method, Pharmacologic Management
Introduction: In the absence of high-quality evidence for Coronavirus disease-2019 (COVID-19), supportive care is advocated during this pandemic. We aim to develop a consensus statement from global experts for pharmacological management, based on the pathophysiology of COVID-19.
Material and Methods: We used a modified Delphi methodology in three steps: 1) Formulation of the steering committee and questionnaire; 2) Delphi methodology and selection of experts; 3) Final meeting of the steering committee and analysis, discussion, preparation, and presentation of captured data.
Results: 34 (73·9%) experts accepted the invitation for the study. We conducted two rounds of Delphi and consensus (>70% votes) was achieved on 11 out of 24 statements after the end of round two.
Conclusion: This global consensus suggests that “Anti-viral therapy should be administered in the early infection phase of COVID-19 followed by low dose steroid therapy in pulmonary phase. Prophylactic dose anticoagulation should be used in hospitalized, mild to moderate COVID-19 patients. We make no suggestions for the use of immune modulation therapy”.