Hiroshi Bando1,2* 1Medical Research/Tokushima University, Tokushima, Japan 2Integrative Medicine Japan (IMJ), Shikoku Island division, Tokushima, Japan
Corresponding Author: Hiroshi BANDO, MD, PhD, FACP ORCID iD Address: Tokushima University /Medical Research, Nakashowa 1-61, Tokushima 770-0943, Japan. Received date: 26 March 2021; Accepted date: 17 April 2021; Published date: 27 April 2021
Citation: Bando H. Up-To-Date Perspectives for Hyperuricemia, Cardiorenal Influence and Urate-Lowering Therapy (ULT). Diab Res Open Access. 2021 April 27;3(1):16-19.
Keywords: Hyperuricemia, Urate-Lowering Therapy, Selective Urate Reabsorption Inhibitor, Chronic Kidney Disease, Preventing Early Renal Loss in Diabetes, American College of Rheumatology
Abbreviations: ULT: Urate-Lowering Therapy; SURI: Selective Urate Reabsorption Inhibitor; CKD: Chronic Kidney Disease; PERL: Preventing Early Renal Loss in Diabetes; ACR: American College of Rheumatology
Hyperuricemia is a clinical important problem and its prevalence has been increased. Latest topics are described. The guideline adequately managing gout was published from American College of Rheumatology (ACR). Various optimal uses of urate-lowering therapy (ULT) were presented. The cardiorenal effects of hyperuricemia have been investigated for years. Regarding the patients on chronic kidney disease (CKD) and high risk of progression, ULT with allopurinol did not show the decline in eGFR compared to the control. Recently, dotinurad that is a new selective urate reabsorption inhibitor (SURI) would be applied to medical practice. Low-dose dotinurad showed satisfactory pharmacological efficacy.