The Role of Mutations on Gene WNT4 in Müllerian Aplasia and Hyperandrogenism Syndrome

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The Role of Mutations on Gene WNT4 in Müllerian Aplasia and Hyperandrogenism Syndrome

Zahra Gholizadeh1, Shahin Asadi2iD*
1Division of Medical Genetics and Molecular Pathology Research, Harvard University, Boston Children's Hospital, United States
2Medical Genetics Harvard University, Director of The Division of Medical Genetics and Molecular Optogenetic Research, Boston Children's Hospital, United States

Corresponding Author: Shahin Asadi ORCID iD
Address: Medical Genetics Harvard University, Director of The Division of Medical Genetics and Molecular Optogenetic Research, Boston Children's Hospital, United States.
Received date: 11 September 2022; Accepted date: 01 October 2022; Published date: 08 October 2022

Citation: Gholizadeh Z, Asadi S. The Role of Mutations on Gene WNT4 in Müllerian Aplasia and Hyperandrogenism Syndrome. J Health Care and Research. 2022 Oct 08;3(3):68-72.

Copyright © 2022 Gholizadeh Z, Asadi S. This is an open-access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium provided the original work is properly cited.

Keywords: WNT4 deficiency, Genetic Mutation, WNT4 Gene, Infertility

Abstract

Molar aplasia and hyperandrogenism is a genetic disorder that affects the reproductive system in women. This condition is caused by abnormal growth of the molar ducts, which are structures in the fetus that form into the uterus, fallopian tubes, cervix, and upper vagina. A mutation in the WNT4 gene, located at the short arm of chromosome 1 at 1p36.12, causes molar aplasia and hyperandrogenism. This gene belongs to a family of WNT genes that play an important role in evolution before birth.