Risk Factors Associated With Hyperuricemia in Patients with Diabetes Type 2: About 190 Cases

Fennoun H^1,2,3, Haraj NE^1,2,3, El Aziz S^1,2,3, Bensbaa S^1,2,3, Chadli A^1,2,3

¹Endocrinology, Diabetology and Metabolic Diseases Department, Ibn Rochd University Hospital of Casablanca, Morocco

²Laboratory of Neuroscience and Mental Health Clinic, Morocco

³Faculty of Medicine and Pharmacy, University Hassan II, Casablanca, Morocco

Corresponding Author: Asma Chadli

Address: Endocrinology, Diabetology, and Metabolic Diseases Department, Ibn Rochd University Hospital of Casablanca, Morocco; Tel: +212 6 61092820; E-mail: drachadli@gmail.com

Received date: 08 April 2020; Accepted date: 25 April 2020; Published date: 04 May 2020

Citation: Fennoun H, Haraj NE, El Aziz S, Bensbaa S, Chadli A. Risk Factors Associated With Hyperuricemia in Patients with Diabetes Type 2: About 190 Cases. Diab Res Open Access. 2020 May 4;2(1):12-16.

Copyright © 2020 Fennoun H, Haraj NE, El Aziz S, Bensbaa S, Chadli A. This is an open-access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Keywords: Hyperuricemia, Metabolic Syndrome, Type 2 Diabetes, Uric Acid

Abstract

Introduction: Hyperuricemia is common Type 2 diabetes at very high cardiovascular risk.

Objective: Evaluate the relationship between hyperuricemia and diabetes type 2, and determine its predictive factors in this population.

Patients and Methods: Retrospective study cross including 190 patients with diabetes type 2 hospitalized Service of Endocrinology of CHU Ibn Rushd Casablanca from January 2015 to December 2017. Hyperuricemia was defined as a serum uric acid concentration> 70 mg/L (men) and> 60 mg/L (women). The variables studied were the anthropometric measurements), cardiovascular factors (tobacco, hypertension, dyslipidemia), and degenerative complications (retinopathy, neuropathy, kidney failure, ischemic heart disease). The analyzes were performed by SPSS software.

Results: Hyperuricemia was found in 26.5% of patients with a female predominance (76%), an average age of 55.9 years, and an average age of 12.4ans diabetes. The glycemic control was found in 84.6% of cases with mean glycated hemoglobin 8.6%.

Factors associated al hyperuricemia were the blood pressure in 86% (p <0.05), dyslipidemia in 76.3% of cases (p <0.001) with hypertriglyceridemia in 48.3% of cases (p <0.02), and a hypoHDLémie 28% (p <0.001). The age, obesity, smoking, and glycemic control were associated significantly n al hyperuricemia.

The research of degenerative complications of hyperuricemia has objectified renal impairment (GFR between 15 and 60ml / min) chez47% (p <0.001), it was kind of moderate in 35.8% (p <0.01) and severe in 5.1% (p <0.02), ischemic heart disease was found in 34% of cases (p <0.01).

Conclusion: In our study, hyperuricemia in type 2 diabetes is common in female patients, especially with hypertension, dyslipidemia, and renal failure. Other factors such as age, obesity, smoking is not associated with hyperuricemia in type 2 diabetics.

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