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Recent Perspectives for Clinical Effects of Whey Protein on Post-Prandial Hyperglycemia (PPH)
Hiroshi Bando1,2iD*, Hidehisa Urasaki1,2, Masahiro Bando1
1Medical Research/Tokushima University, Tokushima, Japan
2Yoshinogawa Hospital, Tokushima, Japan
Corresponding Author: Hiroshi Bando ORCID iD
Address: Tokushima University /Medical Research, Nakashowa 1-61, Tokushima 770-0943, Japan.
Received date: 18 September 2025; Accepted date: 18 October 2025; Published date: 24 October 2025
Citation: Bando H, Urasaki H, Bando M. Recent Perspectives for Clinical Effects of Whey Protein on Post-Prandial Hyperglycemia (PPH). Asp Biomed Clin Case Rep. 2025 Oct 24;8(3):287-90.
Copyright © 2025 Bando H, Urasaki H, Bando M. This is an open-access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium provided the original work is properly cited.
Keywords: Whey Protein, Post-Prandial Hyperglycemia, Incremental Area Under the Curves, Dairy Matrix, Biomarkers of Food Intake
Abbreviations: PPH: Post-Prandial Hyperglycemia; AUCs: Incremental Area Under the Curves; BFIs: Biomarkers of Food Intake
Abstract
As the development of continuous glucose monitoring (CGM) progresses, the clinical effects of whey protein on postprandial hyperglycemia (PPH) have been identified. Whey protein includes milk protein, yogurt, casein, almond milk, and so on. Milk protein supplementation has been shown to reduce fasting blood glucose (FBG) by -1.83 mg/dL, fasting insulin by -1.06 μU/mL, and HOMA-IR by -0.27. Whey protein was administered in doses of 0–30 g before breakfast, and the incremental area under the curve (AUC) was reduced when taking 15–30 g. Premeal whey showed a lower glucose peak by -1.0 mmol/L (-18 mg/dL) in patients with gestational diabetes mellitus (GDM). Further research development is expected for PPH.