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Recent Advances in Understanding the Pathophysiology and Risk Stratification of Post-Intubation Hypotension
E Pan1, Yao Chen1*
1Emergency Department, West China Hospital, West China School of Medicine, Sichuan University, Chengdu, China
Corresponding Author: Yao Chen
Address: Emergency Department, Sichuan University West China Hospital, No. 37, Guoxue Alley, Wuhou District, Chengdu, Sichuan Province, 610041 China.
Received date: 17 November 2024; Accepted date: 11 December 2024; Published date: 18 December 2024
Citation: Pan E, Chen Y. Recent Advances in Understanding the Pathophysiology and Risk Stratification of Post-Intubation Hypotension. Asp Biomed Clin Case Rep. 2024 Dec 18;8(1):20-29.
Copyright © 2024 Pan E, Chen Y. This is an open-access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium provided the original work is properly cited.
Keywords: Tracheal Intubation, Hypotension, Mechanisms, Risk Factors, Research Advances
Abstract
Research indicates that post-intubation hypotension (PIH) is the most frequent complication of intubation, potentially leading to acute myocardial infarction, renal failure, extended hospitalizations, and poor outcomes. Key physiological parameters such as age, body mass index, and baseline blood pressure are closely linked to PIH incidence. Induction drugs significantly influence the mechanisms of PIH, with varying drugs and administration methods impacting hemodynamic stability. Furthermore, the complexity of the intubation procedure exacerbates PIH by stimulating the vagus nerve and affecting cardiac output. Although current research aims to identify risk factors and physiological mechanisms of PIH, the absence of uniform diagnostic criteria impedes the comparability of results. Future studies should focus on establishing clear diagnostic standards, optimizing induction drug choices and procedural techniques, and integrating early warning indicators with personalized intervention strategies to decrease PIH incidence and enhance patient outcomes.