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Rapid Reduction of HbA1c and Weight in Elderly Patient with Type 2 Diabetes (T2D) And Depression by Oral Semaglutide (Rybelsus)
Hiroshi BANDO1,2,3*, Kenji HAYASHI3, Kyoko SUMITOMO3, Kazuya MIKI3, Asami KAMOTO3
1Tokushima University / Medical Research, Tokushima, Japan
2Japan Low Carbohydrate Diet Promotion Association (JLCDPA), Kyoto, Japan
3Hayashi Hospital, Tokushima, Japan
Corresponding Author: Hiroshi BANDO, MD, PhD, FACP ORCID iD
Address: Tokushima University /Medical Research, Nakashowa 1-61, Tokushima 770-0943, Japan.
Received date: 27 June 2022; Accepted date: 16 July 2022; Published date: 23 July 2022
Citation: Bando H, Hayashi K, Sumitomo K, Miki K, Kamoto A. Rapid Reduction of HbA1c and Weight in Elderly Patient with Type 2 Diabetes (T2D) And Depression by Oral Semaglutide (Rybelsus). Asp Biomed Clin Case Rep. 2022 Jul 23;5(2):73-78.
Keywords: Oral Semaglutide, Rybelsus, Sodium N-(8-[2-Hydroxybenzoyl] Amino) Caprylate, Geriatric Depression Scale, Mirtazapine, Noradrenergic and Specific Serotonergic Antidepressant, Multiple Meta-Analyses of New Generation Antidepressants Study
Abbreviations: SNAC: Sodium N-(8-[2-Hydroxybenzoyl] Amino) Caprylate; GDS: Geriatric Depression Scale; NASSA: Noradrenergic and Specific Serotonergic Antidepressant; MANGA: Multiple Meta-Analyses of New Generation Antidepressants Study
Background: Oral semaglutide (Rybelsus) has been in focus for type 2 diabetes (T2D).
Case Presentation: The patient is a 73-year-old male with T2D treated with metformin, Ipragliflozin, and rosuvastatin. He was diagnosed with depression by the Geriatric depression scale (GDS) with a stable condition by mirtazapine. His diabetic control was exacerbated to HbA1c 8.8% and weight 63.5kg in Feb 2022.
Results: He started to take Rybelsus, and then clinical improvement was found as HbA1c 6.9% and weight 57.5kg for 4 months.
Discussion: Remarkable effect of HbA1c and weight may be from longer fasting time after post-med, and regular lifestyle from the stable psychosomatic situation.