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Latest Development of Administration Routes for Anti-Diabetic Agents using Insulin Nanoparticles (NPs)
Hiroshi BANDO1,2iD*
1Tokushima University / Medical Research, Tokushima, Japan
2Japan Low Carbohydrate Diet Promotion Association, Kyoto, Japan
Corresponding Author: Hiroshi BANDO, MD, PhD, FACP ORCID iD
Address: Tokushima University /Medical Research, Nakashowa 1-61, Tokushima 770-0943, Japan.
Received date: 21 November 2022; Accepted date: 28 December 2022; Published date: 05 January 2023
Citation: Bando H. Latest Development of Administration Routes for Anti-Diabetic Agents using Insulin Nanoparticles (NPs). Asp Biomed Clin Case Rep. 2023 Jan 05;5(3):165-68.
Copyright © 2022 Bando H. This is an open-access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium provided the original work is properly cited.
Keywords: Nanoparticles, Permeation Enhancers, Sodium N-[8-(2-Hydroxybenzoyl) Amino] Caprylate, Spray Drying, Aqueous Polymer Dispersions, Self-Nanoemulsifying Drug Delivery System
Abbreviations: NPs: Nanoparticles; PEs: Permeation Enhancers; SNAC: Sodium N-[8-(2-Hydroxybenzoyl) Amino] Caprylate; APDs: Aqueous Polymer Dispersions; SNEDDS: Self-Nanoemulsifying Drug Delivery System
Abstract
For the latest development for anti-diabetic agents, nanoparticles (NPs) have been in focus. Permeation enhancers (PEs) are known to increase the oral absorption of various kinds of macromolecules. One of PEs would be sodium N-[8-(2-hydroxybenzoyl) amino] caprylate (SNAC), which has been used for glucagon-like peptide-1 receptor agonist (GLP-1RA) as oral semaglutide (Rybelsus). For insulin encapsulation, polyelectrolyte nanocomplex (PEC) have been the promising carriers. Furthermore, spray drying technique has been an adequate and well-known industrial method for developing pharmaceutical industries, and aqueous polymer dispersions (APDs) have been applied. Consequently, self-nanoemulsifying drug delivery systems (SNEDDS) can be expected to improve future diabetic treatment.