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A Diabetic Male with Metabolic Syndrome (Met-S) Treated by Low Carbohydrate Diet (LCD) and Oral Semaglutide

Tomoya Ogawa¹, Hiroshi Bando^1,2,3iD*, Maki Okada¹, Noboru Iwatsuki¹, Kazuki Sakamoto^1
1Sakamoto Hospital, Higashi Kagawa city, Kagawa, Japan
²Medical Research/Tokushima University, Tokushima, Japan
³Japan Low Carbohydrate Diet Promotion Association, Kyoto, Japan

Corresponding Author: Hiroshi Bando ^{ORCID iD}
Address: Tokushima University /Medical Research, Nakashowa 1-61, Tokushima 770-0943, Japan.
Received date: 05 August 2025; Accepted date: 05 September 2025; Published date: 11 September 2025

Citation: Ogawa T, Bando H, Okada M, Iwatsuki N, Sakamoto K. A Diabetic Male with Metabolic Syndrome (Met-S) Treated by Low Carbohydrate Diet (LCD) and Oral Semaglutide. Diab Res Open Access. 2025 Sept 11;6(1):11-15.

Copyright © 2025 Ogawa T, Bando H, Okada M, Iwatsuki N, Sakamoto K. This is an open-access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium provided the original work is properly cited.

Keywords: Metabolic Syndrome, Low Carbohydrate Diet, Oral Semaglutide, Rybelsus, Pulse Wave Velocity, Type 2 Diabetes

Abbreviations: Met-S: Metabolic Syndrome; LCD: Low Carbohydrate Diet; PWV: Pulse Wave Velocity; T2D: Type 2 Diabetes

Abstract

The patient was a 51-year-old male with metabolic syndrome (Met-S). Actually, he showed several problems of obesity as BMI 35.0 kg/m², type 2 diabetes (T2D), fatty liver, chronic kidney disease (CKD), hyperuricemia, and dyslipidemia. Positive biochemistry data included AST 126 U/L, ALT 143 U/L, UA 8.2 mg/dL, Cre 1.02 mg/dL, LDL 129 mg/dL, and HbA1c 6.3%, with a normal range of pulse wave velocity (PWV). He was treated by a low-carbohydrate diet (LCD) as diet therapy, continuing weight control by LCD, oral hypoglycemic agents (OHAs), and oral semaglutide (Rybelsus) as GLP-1RA. Then, his weight decreased 5 kg, and his general status has remained stable for 7 years.