Muneta T1,2, Kawaguchi E1,2, Hayashi M1,2, Bando H2,3*, Ebe K2,4
1Muneta Maternity Clinic, Chiba, Japan
2Japan Low Carbohydrate Diet Promotion Association (JLCDPA), Kyoto, Japan
3Tokushima University/ Medical Research, Tokushima, Japan
4Takao Hospital, Kyoto, Japan
Corresponding Author: Hiroshi Bando, MD, PhD, FACP
Address: Tokushima University /Medical Research, Nakashowa 1-61, Tokushima 770-0943, Japan.
Received date: 06 January 2019; Accepted date: 29 January 2019; Published date: 04 February 2019
In diabetic practice, continuous glucose monitoring (CGM) has been more used for glucose variability. Authors have reported and developed the clinical study of Low Carbohydrate Diet (LCD) and Calorie Restriction (CR) through Japan LCD Promotion Association (JLCDPA). A diabetic case is presented with normalizing glucose variability by LCD meal checked by CGM. Case is 51 years female with type 2 diabetes mellitus (T2DM). At first visit, HbA1c was 10.0%, glucose was 288mg/dL, BMI 39.1, GOT 16IU/mL, HDL-C 33mg/dL, Triglyceride 152mg/dL. CR meal was provided on day-1 to day-5 and LCD meal with 12% carbohydrate on day-6 to day-13. Average glucose value from CGM was 292mg/dL, 235mg/dL, 160mg/dL, 140mg/dL, 124mg/dL in day 3,5,7,9,11 respectively. On day-13, total Ketone bodies (T-KB) 540μmol/L (-131), Acetoacetic acid (AcAc) 86μmol/L (-55) and 3-hydroxybutyric acid (3-OHBA) 454μmol/L (-85). Weight reduction was 5kg on day-14 and 11.2kg on day-70 with BMI 34.6. Thus, LCD showed a remarkable glucose-lowering effect in short term. FreeStyle Libre (Abbott, USA) seems to be a useful apparatus for monitoring the detailed fluctuation of blood glucose. These results would become fundamental and reference data and contribute to the LCD research development in the future.
Citation: Muneta T, Kawaguchi E, Hayashi M, et al., “Normalized glucose variability by Low Carbohydrate Diet (LCD) in CGM study”. Asp Biomed Clin Case Rep, vol.2, no.s1: 22-27, 2019.
Copyright © 2019 Muneta T, Kawaguchi E, Hayashi M, et al., This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Key Words: 3-Hydroxybutyric Acid (3-OHBA); Ketone Bodies; Continuous Glucose Monitoring (CGM); Japan LCD Promotion Association (JLCDPA); FreeStyle Libre
Abbreviation: LCD: Low Carbohydrate Diet; T2DM: Type 2 Diabetes Mellitus; CR: Calorie Restriction; JLCDPA: Japan LCD Promotion Association; AcAc: Acetoacetic acid; 3-OHBA: 3-Hydroxybutyric Acid