Journal of Health Care and Research

Journal of Health Care and Research [ISSN: 2582-8967]

Kai Ahmavaara¹, George Ayoub^1*
1Psychology Dept, Santa Barbara City College, Santa Barbara, California 93109 USA

Corresponding Author: George Ayoub
Address: Psychology Dept, Santa Barbara City College, Santa Barbara, California 93109 USA.
Received date: 31 December 2023; Accepted date: 31 January 2024; Published date: 07 February 2024

Citation: Ahmavaara K, Ayoub G. Stress and Folate Impact Neurodevelopmental Disorders. J Health Care and Research. 2024 Feb 07;5(1):1-6.

Copyright © 2024 Ahmavaara K, Ayoub G. This is an open-access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium provided the original work is properly cited.

Keywords: Autism Spectrum Disorder, Folate Receptor Antibody, Cerebral Folate Deficiency, Reduced Folate, Folinic Acid, Prenatal Supplementation

Abstract

Autism Spectrum Disorder (ASD) is one of several developmental disabilities that can create significant communication and behavioral challenges in affected individuals. Several studies have found that children with ASD have high levels of Folate Receptor Antibody (FRA), which blocks the transport of folate across the Blood-Brain Barrier (BBB) and leads to Cerebral Folate Deficiency (CFD). Supplementation with folate in its reduced form, such as with folinic acid, has been found to improve communication in autistic children with folate receptor antibodies. Here, we provide an overview of the role of folate in nervous system development, effects of FRA on brain folate levels, and clinical trials that have examined the efficacy of folate supplementation in reducing the symptoms of developmental disabilities. Further, we highlight the importance of prenatal folate supplementation in reducing the risk and severity of developmental disorders and the need for additional research to explore optimal dietary interventions to aid in managing them. The results suggest that supplementing with reduced folate may offer a promising treatment approach for individuals with neurodevelopmental disorders, particularly those with FRA.