Corresponding Author: Hiroshi BANDO, MD, PhD, FACP ORCID iD Address: Tokushima University /Medical Research, Nakashowa 1-61, Tokushima 770-0943 Japan. Received date: 30 December 2020; Accepted date: 13 January 2021; Published date: 21 January 2021
Citation: Bando H. Type 2 Diabetes Mellitus (T2DM) may have Four Subtypes Beneficial for Adequate Treatment. Asp Biomed Clin Case Rep. 2021 Jan 21;4(1):38-41.
Keywords: Type 2 diabetes mellitus (T2DM), Subtype, Cluster, All New Diabetes in Scania (ANDIS)
Abbreviations: Type 2 diabetes mellitus (T2DM); All New Diabetes in Scania (ANDIS)
Diabetes includes various heterogeneous factors. Similar to subtypes of type 1 diabetes, type 2 diabetes may show four subtype clusters. They are cluster A: severe insulin-deficient diabetes, B: severe insulin-resistant diabetes, C: mild obesity-related diabetes, and D: mild age-related diabetes. Comparing them, the prevalence of nephropathy and cardiovascular events was highest in the cluster A. Reference data are i) the ratio of cluster A-D is 18.7%, 23.7%, 21.1%, 36.4%, ii) HbA1c for A-D is 11.05%, 8.17%, 8.49%, 7.95%, iii) event ratio of MACE is 14.4%, 10.6%, 11.4%, 9.1%. Future diabetic treatment is hopefully provided suitable for each subtype.