Seasonal Variation of Glucose Variability in Rather Elderly Patients with Type 2 Diabetes (T2D) Treated by Vildagliptin and Metformin (EquMet)

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Seasonal Variation of Glucose Variability in Rather Elderly Patients with Type 2 Diabetes (T2D) Treated by Vildagliptin and Metformin (EquMet)

Hiroshi BANDO1,2,3iD*, Hisako YAMASHITA3, Yoshinobu KATO3, Takafumi KAWATA3, Yoshikane KATO3, Hiroe KANAGAWA3
1Tokushima University / Medical Research, Tokushima, Japan
2Japan Low Carbohydrate Diet Promotion Association, Kyoto, Japan
3Kanaiso Hospital, Tokushima, Japan

Corresponding Author: Hiroshi BANDO, MD, PhD, FACP ORCID iD
Address: Tokushima University /Medical Research, Nakashowa 1-61, Tokushima 770-0943, Japan.
Received date: 24 September 2022; Accepted date: 15 October 2022; Published date: 22 October 2022

Citation: Bando H, Yamashita H, Kato Y, Kawata T, Kato Y, Kanagawa H. Seasonal Variation of Glucose Variability in Rather Elderly Patients with Type 2 Diabetes (T2D) Treated by Vildagliptin and Metformin (EquMet). Asp Biomed Clin Case Rep. 2022 Oct 22;5(3):146-51.

Copyright © 2022 Bando H, Yamashita H, Kato Y, Kawata T, Kato Y, Kanagawa H. This is an open-access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium provided the original work is properly cited.

Keywords: Seasonal variation of HbA1c, Type 2 Diabetes, Cardiovascular Disease, EquMet, Ramadan

Abbreviations: T2D: Type 2 Diabetes; CVD: Cardiovascular Disease

Abstract

Background: Seasonal variation of HbA1c has been in focus.
Patients and Methods: The protocol included type 2 diabetes (T2D) patients (n=26, 71.4±10.2 years) on vildagliptin and metformin (EquMet) and HbA1c changes in 4 seasons for 6 years.
Results: HbA1c values ranged 6.9-7.5%, and tend to show highest in winter, and rather lower in autumn.
Discussion & Conclusion: Rather elderly T2D cases can tolerate EquMet with fair control. Previous reports showed a similar tendency. Some factors may be involved in the variation, such as temperature, climate, carbohydrate intake, Ramadan, and others. Furthermore, blood pressure and cardiovascular disease (CVD) can also influence them.