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Oliceridine: Progress in Clinical Research on a New Analgesic Drug

Ruixue Li^1,2*
1Department of Anesthesiology, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China
²The Research Units of West China (2018RU012), Chinese Academy of Medical Sciences, Chengdu, Sichuan Province, China

Corresponding Author: Ruixue Li
Address: Department of Anesthesiology, West China Hospital, Sichuan University, 37 Guo Xue St, Chengdu, Sichuan 610041, China.
Received date: 08 August 2025; Accepted date: 21 August 2025; Published date: 28 August 2025

Citation: Li R. Oliceridine: Progress in Clinical Research on a New Analgesic Drug. Asp Biomed Clin Case Rep. 2025 Aug 28;8(3):250-55.

Copyright © 2025 Li R. This is an open-access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium provided the original work is properly cited.

Keywords: Oliceridine, Analgesic Drug, Clinic

Abstract

Oliceridine is a new class of μ-opioid receptor agonists, which is relatively selective to μ-opioid receptors and exerts analgesic effects by interacting with μ-opioid receptors (MORS). Compared with morphine, it has the characteristics of fast onset, strong analgesic effect, low incidence of respiratory depression and gastrointestinal adverse reactions, and less neurological complications. It is a safe and effective intravenous analgesic, providing a better choice for the treatment of patients with moderate to severe acute pain. In this paper, the mechanism of action, pharmacodynamics and pharmacokinetics, clinical application and development trend of oliceridine were reviewed, so as to provide theoretical basis for clinical application.