- Version
- Download 74125
- File Size 0.00 KB
- File Count 1
- Create Date May 21, 2026
- Last Updated May 21, 2026
Improvement of HbA1c and LDL-C by Imeglimin (Twymeeg) in the Diabetic Female Elderly
Tomoya Ogawa1, Hiroshi Bando1,2,3iD*, Noboru Iwatsuki1, Maki Okada1, Kazuki Sakamoto1
1Sakamoto Hospital, Higashi Kagawa city, Kagawa, Japan
2Tokushima University / Medical Research, Tokushima, Japan
3Japan Low Carbohydrate Diet Promotion Association, Kyoto, Japan
Corresponding Author: Hiroshi Bando ORCiD
Address: Tokushima University /Medical Research, Nakashowa 1-61, Tokushima 770-0943, Japan.
Received date: 9 April 2026; Accepted date: 11 May 2026; Published date: 18 May 2026
Citation: Ogawa T, Bando H, Iwatsuki N, Okada M, Sakamoto K. Improvement of HbA1c and LDL-C by Imeglimin (Twymeeg) in the Diabetic Female Elderly. Asp Biomed Clin Case Rep. 2026 May 18;9(2):66-70.
Copyright © 2026 Ogawa T, Bando H, Iwatsuki N, Okada M, Sakamoto K. This is an open-access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium provided the original work is properly cited.
Keywords: Petite Low-Carbohydrate Diet, Pulse Wave Velocity, Japan LCD Promotion Association, Oral Hypoglycemic Agent, Trials of IMeglimin for Efficacy and Safety
Abbreviations: LCD: Low-Carbohydrate Diet; PWV: Pulse Wave Velocity; JLCDPA: Japan LCD Promotion Association; OHA: Oral Hypoglycemic Agent; TIMES: Trials Of IMeglimin For Efficacy And Safety; T2D: Type 2 Diabetes; GERD: Gastroesophageal Reflux Disease; CAVI: Cardio-Ankle Vascular Index; ABI: Ankle-Brachial Index.
Abstract
The case is a 77-year-old female who was treated for arteriosclerosis and gastroesophageal reflux disease (GERD). In March 2025, type 2 diabetes (T2D) was detected, with HbA1c of 8.8%. Physical examination was negative, with BMI of 21.7 kg/m². Blood chemistry examination revealed LDL of 142 mg/dL, and pulse wave velocity (PWV) showed a cardio-ankle vascular index (CAVI) of 9.9/9.6 and ankle-brachial index (ABI) of 1.11/1.07.
She was advised to follow a petite low-carbohydrate diet (LCD), treated with imeglimin (Twymeeg), and subsequently received rosuvastatin, vildagliptin, and metformin. As a result, she showed improvement, with HbA1c of 7.0% and LDL of 78 mg/dL in March 2026, indicating remarkable clinical efficacy.