Dolhyi V1, Avierin D1, Hojouj M1, Bondarenko I1
1State Establishment “Dnipropetrovsk Medical Academy“, of Health Ministry of Ukraine
Corresponding Author: Hojouj Mohammad, MD, MSo, PH
Address: Associate Professor, Dept Oncology and Medical Radiology, Dnepropetrovsk Medical Academy, 31, Blyzhnya Str., Dnepropetrovsk, 49102, Ukraine; E-mail: firstname.lastname@example.org
Received date: 22 August 2019; Accepted date: 29 August 2019; Published date: 05 September 2019
This review work is done to show a significance of tubulin in cancer development. Within last decades there are a lot of studies have performed in this area. Now it is clear that there are an enormous number of functions in cell performing by microtubules, a structure unit of which is tubulin. Now it used widely as a predictive factor of tumor aggressiveness, but increasingly it becomes a target for studying and treatment elaboration, since it is well-known that to nowadays tubulin-targeted medicines, such as taxanes or vinca-alkaloids, resistance develops rather quickly, so it consists a large problem in oncology. This work reveals basic microtubule functions, violations that it may undergo and consequences of these. Also it is described here the main modern tendencies in creation of remedy which will make it possible breakthrough treatment resistance barrier.
Citation: Dolhyi V, Avierin D, Hojouj M, Bondarenko I. Tubulin Role in Cancer Development and Treatment. Asp Biomed Clin Case Rep. 2019 Sept 5;2(2):15-22.
Copyright © 2019 Dolhyi V, Avierin D, Hojouj M, Bondarenko I. This is an open-access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Key Words: Tubulin; Cancer Development; Malignant Neoplasm; Microtubules; Centrosomes