1Assistant Professor, Department of chemical Sciences, Sree Vidyanikethan Degree College, A.P, India
Corresponding Author: Eswari Beeram
Address: Assistant Professor, Department of chemical Sciences, Sree Vidyanikethan Degree College, A.P, India; E-mail: firstname.lastname@example.org
Received date: 11 October 2019; Accepted date: 22 October 2019; Published date: 29 October 2019
RNase H1 generally processes the RNA- DNA hybrids through non specific interaction between HBD and the ds RNA/DNA hybrid. There are no direct protein- protein interactions between the hybrid and HBD of RNase H1. The DNA binding region is highly conserved compared to RNA binding region and the Kd for RNA/DNA hybrid is less compared to ds RNA than to that of ds DNA. HBD increases the processivity of RNase H1 and mutations in RNA binding region is tolerated compared to DBR. The RNA interacts between ɑ2 and β3 region with in the loop and with the protein in shallower minor groove.
Citation: Beeram E. Mini review on Protein – Protein and DNA/RNA – protein interactions in biology. Asp Biomed Clin Case Rep. 2019 Oct 29;2(2):82-83.
Copyright © 2019 Beeram E. This is an open-access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Keywords: Protein; DNA/RNA; Biology