Asploro Journal of Biomedical and Clinical Case Reports
Article Type: Case Report
Asp Biomed Clin Case Rep. 2021 Oct 27;4(3):179-83
Lewkowicz María de los Milagros¹*, Greco Daniel Alejandro¹, Lezcano Félix Gabriel¹, Cachau Victoria¹, Díaz de la Fuente Florencia¹
¹Hospital de Clínicas “José de San Martin”, División Dermatopatología, Ciudad de Buenos Aires, Argentina
Corresponding Author: Lewkowicz María de los Milagros ORCID iD
Address: Hospital de Clínicas “José de San Martin”, División Dermatopatología, Ciudad de Buenos Aires, Argentina.
Received date: 13 September 2021; Accepted date: 18 October 2021; Published date: 27 October 2021
Citation: Lewkowiz M, Greco A, Lezcano G, Cachau V, Diaz de la Fuente F. Case Report and Highlight Clues on the Diagnosis of Pilomatrical Carcinoma. Asp Biomed Clin Case Rep. 2021 Oct 27;4(3):179-83.
Copyright © 2021 Lewkowiz M, Greco A, Lezcano G, Cachau V, Diaz de la Fuente F. This is an open-access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium provided the original work is properly cited.
Keywords: Case Report, Pilomatrical Carcinoma, Cutaneous Adnexal Tumors, Pilomatrixoma
Pilomatrical Carcinoma (PC) is a rare malignant adnexal tumor with matrical differentiation. Its benign counterpart (Pilomatrixoma) is diagnosed much more frequently in daily pathological practice. Both entities share genetic alterations but the malignant counterpart acquires mutations that make it develop an aggressive behavior .
We describe a 33-year-old man who presented with a 7 x 6 cm nodular ulcerated lesion in the left ear with markedly accelerated growth in the last month. Incisional biopsy was referred to us with suspicion of squamous cell carcinoma versus pyogenic granuloma.
Histologic sections showed ulcerated fragments infiltrated by a basaloid cell proliferation interspersed with groups of “ghost cells”. The neoplastic cells were arranged in irregular sheets with infiltrative borders. Groups of Squamous cells with trichilemmal keratinization and foci of necrosis were also identified. The biopsy was diagnosed as an adnexal neoplasm with pilomatrical differentiation, suggesting its complete resection with safety margins due to the presence of aggressive characteristics. The subsequent study of the excisional biopsy showed similar characteristics to those previously described. Notoriously, focal infiltration of the auricular cartilage was identified, leading us to the undoubted diagnosis of pilomatrical carcinoma.