Ebe K1,2, Bando H2,3*, Muneta T2,4, Bando M5, Yonei Y6
1Takao Hospital, Kyoto, Japan
2Japan Low Carbohydrate Diet Promotion Association (JLCDPA), Kyoto, Japan
3Tokushima University/ Medical Research, Tokushima, Japan
4Muneta Maternity Clinic, Chiba, Japan
5Department of Nutrition and Metabolism, Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima, Japan
6Anti-Aging Medical Research Center, Graduate School of Life and Medical Sciences, Doshisha University, Kyoto, Japan
Corresponding Author: Hiroshi Bando, MD, PhD, FACP
Address: Tokushima University/ Medical Research, Nakashowa 1-61, Tokushima 770-0943 Japan; TEL: +81-90-3187-2485; E-mail: firstname.lastname@example.org
Received date: 13 December 2019; Accepted date: 30 December 2019; Published date: 06 January 2020
Diabetes has been a crucial medical and social problem worldwide. For adequate nutritional therapy, there have been discussions concerning Calorie Restriction (CR) and Low Carbohydrate Diet (LCD). We have investigated glucose variability of diabetic patients applying CR, LCD, continuous glucose monitoring (CGM) and applied FreeStyle Libre which is flash glucose monitoring (FGM). The patient is a 40-year-old female with type 2 diabetes mellitus (T2DM), who showed BMI 20.7, postprandial blood glucose 257 mg/dL. HbA1c 12.1%, Glycoalbumin 31.6% (11.6-16.4), serum C-peptide 2.0 ng/ml and unremarkable data of liver function, renal, lipids. She was provided the intervention of three stages, which are i) CR with 60% carbohydrate in Day 1-2, ii) LCD meal with 12% carbohydrate in Day 3-5; iii) LCD + Sodium-glucose cotransporter 2 (SGLT2) inhibitor (Ipragliflozin L-Proline 50mg) in Day 6-12. The glucose profile was measured by FreeStyle Libre Pro (Abbott) for 14 days. The daily profile of blood glucose was abruptly decreased on Day 6. Time percentage of satisfactory blood glucose 70-180 mg/dL (/24h) was 0%, 0%, 2%, 14%, 0%, 54%, 100% in Day 1-7, respectively. These results suppose the acute clinical efficacy of SGLT2 inhibitor, and this report would become a reference for future diabetic practice and research.
Citation: Ebe K, Bando H, Muneta T, Bando M, Yonei Y. Useful Measurement of Glucose Variability by Flash Glucose Monitoring (FGM) with the Efficacy of Sodium-Glucose Cotransporter 2 (SGLT2) Inhibitor. Diab Res Open Access. 2020 Jan 06;2(S1):1-8.
Copyright © 2020 Ebe K, Bando H, Muneta T, Bando M, Yonei Y. This is an open-access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Keywords: Low Carbohydrate Diet; Continuous Glucose Monitoring; FreeStyle Libre Pro; Flash Glucose Monitoring; Sodium-Glucose Cotransporter 2 (SGLT2) Inhibitor; Japan LCD Promotion Association (JLCDPA)
Abbreviations: LCD: Low Carbohydrate Diet; CGM: Continuous Glucose Monitoring; FGM: Flash Glucose Monitoring; T2DM: Type 2 Diabetes Mellitus; SGLT2: Sodium-Glucose Cotransporter 2; CR: Calorie Restriction