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Risk Factors Associated With Hyperuricemia in Patients with Diabetes Type 2: About 190 Cases | Abstract

Fennoun H1,2,3, Haraj NE1,2,3, El Aziz S1,2,3, Bensbaa S1,2,3, Chadli A1,2,3

1Endocrinology, Diabetology and Metabolic Diseases Department, Ibn Rochd University Hospital of Casablanca, Morocco

2Laboratory of Neuroscience and Mental Health Clinic, Morocco

3Faculty of Medicine and Pharmacy, University Hassan II, Casablanca, Morocco

Corresponding Author: Asma Chadli

Address: Endocrinology, Diabetology, and Metabolic Diseases Department, Ibn Rochd University Hospital of Casablanca, Morocco; Tel: +212 6 61092820; E-mail: drachadli@gmail.com

Received date: 08 April 2020; Accepted date: 25 April 2020; Published date: 04 May 2020

Abstract

Introduction: Hyperuricemia is common Type 2 diabetes at very high cardiovascular risk.

Objective: Evaluate the relationship between hyperuricemia and diabetes type 2, and determine its predictive factors in this population.

Patients and Methods: Retrospective study cross including 190 patients with diabetes type 2 hospitalized Service of Endocrinology of CHU Ibn Rushd Casablanca from January 2015 to December 2017. Hyperuricemia was defined as a serum uric acid concentration> 70 mg/L (men) and> 60 mg/L (women). The variables studied were the anthropometric measurements), cardiovascular factors (tobacco, hypertension, dyslipidemia), and degenerative complications (retinopathy, neuropathy, kidney failure, ischemic heart disease). The analyzes were performed by SPSS software.

Results: Hyperuricemia was found in 26.5% of patients with a female predominance (76%), an average age of 55.9 years, and an average age of 12.4ans diabetes. The glycemic control was found in 84.6% of cases with mean glycated hemoglobin 8.6%.

Factors associated al hyperuricemia were the blood pressure in 86% (p <0.05), dyslipidemia in 76.3% of cases (p <0.001) with hypertriglyceridemia in 48.3% of cases (p <0.02), and a hypoHDLémie 28% (p <0.001). The age, obesity, smoking, and glycemic control were associated significantly n al hyperuricemia.

The research of degenerative complications of hyperuricemia has objectified renal impairment (GFR between 15 and 60ml / min) chez47% (p <0.001), it was kind of moderate in 35.8% (p <0.01) and severe in 5.1% (p <0.02), ischemic heart disease was found in 34% of cases (p <0.01).

Conclusion: In our study, hyperuricemia in type 2 diabetes is common in female patients, especially with hypertension, dyslipidemia, and renal failure. Other factors such as age, obesity, smoking is not associated with hyperuricemia in type 2 diabetics.

Citation: Fennoun H, Haraj NE, El Aziz S, Bensbaa S, Chadli A. Risk Factors Associated With Hyperuricemia in Patients with Diabetes Type 2: About 190 Cases. Diab Res Open Access. 2020 May 4;2(1):12-16.

Copyright © 2020 Fennoun H, Haraj NE, El Aziz S, Bensbaa S, Chadli A. This is an open-access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Keywords: Hyperuricemia, Metabolic Syndrome, Type 2 Diabetes, Uric Acid

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